Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin

CYP3A4 is one of the major drug-metabolizing enzymes in human and is responsible for the metabolism of 60% of clinically used drugs. Many drugs are able to induce the expression of CYP3A4, which usually causes drug-drug interactions and adverse drug reactions. This study aims to explore the role of...

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Veröffentlicht in:	Molecular pharmacology 2017-08, Vol.92 (2), p.113-123
Hauptverfasser:	Yan, Liang, Wang, Yiting, Liu, Jingyang, Nie, Yali, Zhong, Xiao-bo, Kan, Quancheng, Zhang, Lirong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cytochrome P-450 CYP3A - biosynthesis Cytochrome P-450 CYP3A Inducers - pharmacology Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology Histones - metabolism Humans Pregnane X Receptor Receptors, Steroid - physiology Rifampin - pharmacology
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