PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells
To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and...
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| Veröffentlicht in: | Asian journal of andrology 2017-07, Vol.19 (4), p.453-457 |
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| creator | Yang, Qing Cui, Zi-Lian Wang, Qin Jin, Xun-Bo Zhao, Yong Wang, Mu-Wen Song, Wei Qu, Hua-Wei Kang, Wei-Ting |
| description | To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway. |
| doi_str_mv | 10.4103/1008-682X.178849 |
| format | Article |
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The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway.</description><identifier>ISSN: 1008-682X</identifier><identifier>EISSN: 1745-7262</identifier><identifier>DOI: 10.4103/1008-682X.178849</identifier><identifier>PMID: 27232851</identifier><language>eng</language><publisher>China: Medknow Publications and Media Pvt. Ltd</publisher><subject>Animal research ; Animals ; Apoptosis ; Apoptosis - drug effects ; Cancer cells ; Cell cycle ; Cell Cycle - drug effects ; Cell Proliferation - drug effects ; Cyclin D1 - biosynthesis ; Cyclin D1 - genetics ; Flow cytometry ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene Silencing - drug effects ; Genes ; Genetic aspects ; Genetic Therapy - methods ; Health aspects ; Humans ; Immunoglobulins ; Kinases ; Liver cancer ; LNCaP细胞 ; Lung cancer ; Male ; Medical prognosis ; Metastasis ; Methods ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Original ; Plasmids ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - therapy ; Proteins ; Receptor, ErbB-2 - drug effects ; RNA sequencing ; RNA, Long Noncoding - genetics ; RNA, Small Interfering - genetics ; RNA, Small Interfering - therapeutic use ; Software ; Studies ; Tumorigenesis ; Tumors ; 前列腺癌细胞 ; 基因检测 ; 实时定量PCR ; 细胞凋亡 ; 细胞周期蛋白 ; 诱导 ; 通路</subject><ispartof>Asian journal of andrology, 2017-07, Vol.19 (4), p.453-457</ispartof><rights>COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Jul 2017</rights><rights>Copyright: © The Author(s)(2017) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-b9a9149b9f38475f794c792f971db5e1fb3d63b8ede06911ba178c1e1f40dbcf3</citedby><cites>FETCH-LOGICAL-c549t-b9a9149b9f38475f794c792f971db5e1fb3d63b8ede06911ba178c1e1f40dbcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84127X/84127X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507092/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507092/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27232851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Qing</creatorcontrib><creatorcontrib>Cui, Zi-Lian</creatorcontrib><creatorcontrib>Wang, Qin</creatorcontrib><creatorcontrib>Jin, Xun-Bo</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Wang, Mu-Wen</creatorcontrib><creatorcontrib>Song, Wei</creatorcontrib><creatorcontrib>Qu, Hua-Wei</creatorcontrib><creatorcontrib>Kang, Wei-Ting</creatorcontrib><title>PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells</title><title>Asian journal of andrology</title><addtitle>Asian Journal of Andrology</addtitle><description>To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway.</description><subject>Animal research</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cancer cells</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Cyclin D1 - genetics</subject><subject>Flow cytometry</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Gene Silencing - drug effects</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Therapy - methods</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>LNCaP细胞</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Original</subject><subject>Plasmids</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Proteins</subject><subject>Receptor, ErbB-2 - drug effects</subject><subject>RNA sequencing</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - therapeutic use</subject><subject>Software</subject><subject>Studies</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>前列腺癌细胞</subject><subject>基因检测</subject><subject>实时定量PCR</subject><subject>细胞凋亡</subject><subject>细胞周期蛋白</subject><subject>诱导</subject><subject>通路</subject><issn>1008-682X</issn><issn>1745-7262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt9rFDEQx4MotlbffZJFwbe95udm8yIcpVqhtCIKvoVsNtlN2Uu2SdbS_94cdz16IHmYkPnMl5nvBID3CK4oguQcQdjWTYv_rBBvWypegFPEKas5bvDLcn9Kn4A3Kd1BiAkS4jU4wRwT3DJ0Cm5-TF7_vFnXqHK-X7RJlZrDnENyqcpjDMswlmiqKxNrXM0qjw_qsbDVHEPKKptKK69NrLSZpvQWvLJqSubdPp6B318vf11c1de3375frK9rzajIdSeUQFR0wpKWcma5oJoLbAVHfccMsh3pG9K1pjewEQh1qsynUUlQ2HfakjPwZac7L93G9Nr4HNUk5-g2Kj7KoJw8zng3yiH8lYxBDgUuAp_2AjHcLyZleReW6EvPEpXWuGhwMfhADWoy0nkbipjeuKTlmgqOcfG8LdTqP1Q5vdk4HbyxrrwfFXx-VjAaNeUxhWnJLvh0DMIdqIvZKRp7mBBBuf0BcrtiuV2x3P2AUvLhuTOHgqeVF-DjXnMMfrh3fjgwDceME8IY-Qe1YbVb</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Yang, Qing</creator><creator>Cui, Zi-Lian</creator><creator>Wang, Qin</creator><creator>Jin, Xun-Bo</creator><creator>Zhao, Yong</creator><creator>Wang, Mu-Wen</creator><creator>Song, Wei</creator><creator>Qu, Hua-Wei</creator><creator>Kang, Wei-Ting</creator><general>Medknow Publications and Media Pvt. 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drug effects</topic><topic>Cancer cells</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Cyclin D1 - genetics</topic><topic>Flow cytometry</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Gene Silencing - drug effects</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Therapy - methods</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>LNCaP细胞</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Methods</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Transplantation</topic><topic>Original</topic><topic>Plasmids</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Proteins</topic><topic>Receptor, ErbB-2 - drug effects</topic><topic>RNA sequencing</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Small Interfering - genetics</topic><topic>RNA, Small Interfering - therapeutic use</topic><topic>Software</topic><topic>Studies</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>前列腺癌细胞</topic><topic>基因检测</topic><topic>实时定量PCR</topic><topic>细胞凋亡</topic><topic>细胞周期蛋白</topic><topic>诱导</topic><topic>通路</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Qing</creatorcontrib><creatorcontrib>Cui, Zi-Lian</creatorcontrib><creatorcontrib>Wang, Qin</creatorcontrib><creatorcontrib>Jin, Xun-Bo</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Wang, Mu-Wen</creatorcontrib><creatorcontrib>Song, Wei</creatorcontrib><creatorcontrib>Qu, Hua-Wei</creatorcontrib><creatorcontrib>Kang, Wei-Ting</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Qing</au><au>Cui, Zi-Lian</au><au>Wang, Qin</au><au>Jin, Xun-Bo</au><au>Zhao, Yong</au><au>Wang, Mu-Wen</au><au>Song, Wei</au><au>Qu, Hua-Wei</au><au>Kang, Wei-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells</atitle><jtitle>Asian journal of andrology</jtitle><addtitle>Asian Journal of Andrology</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>19</volume><issue>4</issue><spage>453</spage><epage>457</epage><pages>453-457</pages><issn>1008-682X</issn><eissn>1745-7262</eissn><abstract>To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway.</abstract><cop>China</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>27232851</pmid><doi>10.4103/1008-682X.178849</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal research Animals Apoptosis Apoptosis - drug effects Cancer cells Cell cycle Cell Cycle - drug effects Cell Proliferation - drug effects Cyclin D1 - biosynthesis Cyclin D1 - genetics Flow cytometry Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene Silencing - drug effects Genes Genetic aspects Genetic Therapy - methods Health aspects Humans Immunoglobulins Kinases Liver cancer LNCaP细胞 Lung cancer Male Medical prognosis Metastasis Methods Mice Mice, Nude Neoplasm Transplantation Original Plasmids Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - therapy Proteins Receptor, ErbB-2 - drug effects RNA sequencing RNA, Long Noncoding - genetics RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use Software Studies Tumorigenesis Tumors 前列腺癌细胞 基因检测 实时定量PCR 细胞凋亡 细胞周期蛋白 诱导 通路 |
| title | PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells |
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