Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence

It has previously been shown that the inhibition of L-type calcium channels (LTCCs) decreases alcohol consumption, although the contribution of the central LTCC subtypes Cav1.2 and Cav1.3 remains unknown. Here, we determined changes in Cav1.2 (Cacna1c) and Cav1.3 (Cacna1d) mRNA and protein expressio...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2017-04, Vol.42 (5), p.1058-1069
Hauptverfasser:	Uhrig, Stefanie, Vandael, David, Marcantoni, Andrea, Dedic, Nina, Bilbao, Ainhoa, Vogt, Miriam A, Hirth, Natalie, Broccoli, Laura, Bernardi, Rick E, Schönig, Kai, Gass, Peter, Bartsch, Dusan, Spanagel, Rainer, Deussing, Jan M, Sommer, Wolfgang H, Carbone, Emilio, Hansson, Anita C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Addictions Addictive behaviors Alcohol use Alcoholism - metabolism Alcoholism - physiopathology Amygdala - drug effects Amygdala - metabolism Animals Calcium Channel Blockers - administration & dosage Calcium Channels - metabolism Calcium Channels - physiology Calcium Channels, L-Type - metabolism Calcium Channels, L-Type - physiology Drug-Seeking Behavior Ethanol - administration & dosage Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Kinases Male Membrane Potentials - drug effects Mental disorders Mental health Neurosciences Original Proteins Psychopharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats, Wistar RNA, Messenger Verapamil - administration & dosage
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