Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we de...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-04, Vol.356 (6333), p.44-50
Hauptverfasser:	Bouziat, Romain, Hinterleitner, Reinhard, Brown, Judy J., Stencel-Baerenwald, Jennifer E., Ikizler, Mine, Mayassi, Toufic, Meisel, Marlies, Kim, Sangman M., Discepolo, Valentina, Pruijssers, Andrea J., Ernest, Jordan D., Iskarpatyoti, Jason A., Costes, Léa M. M., Lawrence, Ian, Palanski, Brad A., Varma, Mukund, Zurenski, Matthew A., Khomandiak, Solomiia, McAllister, Nicole, Aravamudhan, Pavithra, Boehme, Karl W., Hu, Fengling, Samsom, Janneke N., Reinecker, Hans-Christian, Kupfer, Sonia S., Guandalini, Stefano, Semrad, Carol E., Abadie, Valérie, Khosla, Chaitan, Barreiro, Luis B., Xavier, Ramnik J., Ng, Aylwin, Dermody, Terence S., Jabri, Bana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Antigens - immunology Autoimmune diseases Celiac disease Celiac Disease - immunology Celiac Disease - virology Conversion Diet Diet - adverse effects Disease Models, Animal Genetic Engineering Gluten Glutens - immunology Government regulations Homeostasis Humans Immune response Immune system Immune Tolerance Immunity Infections Inflammation - immunology Inflammation - virology Interferon Interferon Regulatory Factor-1 - genetics Interferon Regulatory Factor-1 - immunology Interferon Type I - genetics Interferon Type I - immunology Intestines - immunology Intestines - pathology Intestines - virology Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Mice, Transgenic Ovalbumin Receptor, Interferon alpha-beta - genetics Reoviridae Reoviridae - genetics Reoviridae Infections - complications Reoviridae Infections - immunology Small intestine Th1 Cells - immunology Tolerances Viral infections Viruses
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