Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity

Summary We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published geno...

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Veröffentlicht in:	Aging cell 2017-08, Vol.16 (4), p.672-682
Hauptverfasser:	Sutphin, George L., Backer, Grant, Sheehan, Susan, Bean, Shannon, Corban, Caroline, Liu, Teresa, Peters, Marjolein J., Meurs, Joyce B. J., Murabito, Joanne M., Johnson, Andrew D., Korstanje, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Alzheimer's disease Animals Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - antagonists & inhibitors Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Calcineurin Calcium channels Calcium channels (voltage-gated) Calcium Channels - genetics Calcium Channels - metabolism comparative genetics Enzymes Gene expression Gene Expression Regulation, Developmental Gene Ontology Genes Genome Genome-Wide Association Study Homo sapiens Humans Huntington's disease Hydrolases - antagonists & inhibitors Hydrolases - genetics Hydrolases - metabolism Hypoxia Leucine Life span lifespan Longevity Longevity - genetics Molecular Sequence Annotation Muscle Proteins - antagonists & inhibitors Muscle Proteins - genetics Muscle Proteins - metabolism Nematodes Neurodegenerative diseases Original Orthology Proteins - antagonists & inhibitors Proteins - genetics Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-mediated interference Sequence Homology, Amino Acid Signal Transduction Tetraspanins - antagonists & inhibitors Tetraspanins - genetics Tetraspanins - metabolism transcriptomics Worms
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