Quantitative identification of senescent cells in aging and disease

Summary Senescent cells are present in premalignant lesions and sites of tissue damage and accumulate in tissues with age. In vivo identification, quantification and characterization of senescent cells are challenging tasks that limit our understanding of the role of senescent cells in diseases and...

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Veröffentlicht in:	Aging cell 2017-08, Vol.16 (4), p.661-671
Hauptverfasser:	Biran, Anat, Zada, Lior, Abou Karam, Paula, Vadai, Ezra, Roitman, Lior, Ovadya, Yossi, Porat, Ziv, Krizhanovsky, Valery
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Aging - pathology Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Biomarkers - analysis cancer cellular senescence Cellular Senescence - drug effects Cellular Senescence - genetics Epithelial Cells - metabolism Epithelial Cells - pathology Etoposide - pharmacology Fibrosis Flow Cytometry Gene Expression Histones - genetics Histones - metabolism HMGB1 Protein - genetics HMGB1 Protein - metabolism Humans Image processing Image Processing, Computer-Assisted ImageStreamX Lymphocytes - metabolism Lymphocytes - pathology Mice Molecular Imaging Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Original Primary Cell Culture Senescence senescence‐associated beta‐galactosidase Single-Cell Analysis - methods Staining and Labeling - methods Stromal Cells - metabolism Stromal Cells - pathology β-Galactosidase
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