Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial

We compared three benidipine-based regimens-that is, benidipine plus angiotensin receptor blocker (ARB), β-blocker (BB) or thiazide-and found that the benidipine-BB combination was less beneficial in reducing the risk of stroke than the benidipine-thiazide combination. This sub-analysis sought to co...

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Veröffentlicht in:	Hypertension research 2017-04, Vol.40 (4), p.376-384
Hauptverfasser:	Umemoto, Seiji, Ogihara, Toshio, Matsuzaki, Masunori, Rakugi, Hiromi, Ohashi, Yasuo, Saruta, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Blood Pressure Determination Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Dihydropyridines - pharmacology Dihydropyridines - therapeutic use Drug Therapy, Combination Female Heart Rate - drug effects Humans Hypertension - drug therapy Male Middle Aged Original Sodium Chloride Symporter Inhibitors - pharmacology Sodium Chloride Symporter Inhibitors - therapeutic use Treatment Outcome
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Zusammenfassung:	We compared three benidipine-based regimens-that is, benidipine plus angiotensin receptor blocker (ARB), β-blocker (BB) or thiazide-and found that the benidipine-BB combination was less beneficial in reducing the risk of stroke than the benidipine-thiazide combination. This sub-analysis sought to compare the effects of reaching a target blood pressure (BP) (
ISSN:	0916-9636 1348-4214
DOI:	10.1038/hr.2016.158