Changes of cortical connectivity during deep anaesthesia

Changes of cortical connectivity during deep anaesthesia

The aim of this study was to evaluate the frontal intracortical connectivity during deep anaesthesia (burst-suppression). Experiments were carried out on 5 adult Sprague Dawley rats. The anaesthesia was induced and maintained with isoflurane. Following the induction of anaesthesia, rats were placed...

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Veröffentlicht in:Romanian journal of anaesthesia and intensive care 2015-10, Vol.22 (2), p.83-88
Hauptverfasser: Pavel, Bogdan, Acatrinei, Camelia Alexandra, Menardy, Fabien, Zahiu, Carmen Mihaela Denise, Popa, Daniela, Zagrean, Ana-Maria, Zagrean, Leon
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container_issue 2
container_start_page 83
container_title Romanian journal of anaesthesia and intensive care
container_volume 22
creator Pavel, Bogdan
Acatrinei, Camelia Alexandra
Menardy, Fabien
Zahiu, Carmen Mihaela Denise
Popa, Daniela
Zagrean, Ana-Maria
Zagrean, Leon
description The aim of this study was to evaluate the frontal intracortical connectivity during deep anaesthesia (burst-suppression). Experiments were carried out on 5 adult Sprague Dawley rats. The anaesthesia was induced and maintained with isoflurane. Following the induction of anaesthesia, rats were placed in a stereotactic instrument. A hole was drilled in the skull over the frontal cortex and electrodes were inserted in order to record the local field potentials. Rats were maintained in deep level anaesthesia (burst-suppression). The cortical connectivity was assessed by computing the coherence spectra. The frontal intracortical connectivity was calculated during burst, suppression (non-burst) and slow wave anaesthesia periods. The global cortical connectivity (0.5-100 Hz) was 0.61 ± 0.078 during the burst periods compared to 0.55 ± 0.032 (p < 0.05) during the suppression periods and 0.55 ± 0.015 (p < 0.05) during slow wave anaesthesia. The global cortical connectivity increased during the burst periods compared to the suppression periods and slow wave anaesthesia. This increase in the cortical synchronization might be due to the subcortical origin of the bursts.
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title Changes of cortical connectivity during deep anaesthesia
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