Production of a gonadotropin-releasing hormone 2 receptor knockdown (GNRHR2 KD) swine line

Swine are the only livestock species that produce both the second mammalian isoform of gonadotropin-releasing hormone (GNRH2) and its receptor (GNRHR2). Previously, we reported that GNRH2 and GNRHR2 mediate LH-independent testosterone secretion from porcine testes. To further explore this ligand-rec...

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Veröffentlicht in:	Transgenic research 2017-08, Vol.26 (4), p.567-575
Hauptverfasser:	Desaulniers, A. T., Cederberg, R. A., Mills, G. A., Lents, C. A., White, B. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Animal Genetics and Genomics animal models Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - growth & development Biomedical and Life Sciences Biomedical Engineering/Biotechnology blood serum boars Body size Body weight Brief Communication Embryos Female females Gene Expression Regulation Gene Knockdown Techniques Genetic Engineering genetically modified organisms Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - biosynthesis Gonadotropin-Releasing Hormone - genetics Gonadotropins Hemizygote Hogs Life Sciences Livestock Luteinizing hormone Luteinizing Hormone - blood Male Males Mammals messenger RNA Molecular Medicine mRNA nucleotide sequences piglets Pituitary (anterior) Plant Genetics and Genomics progeny Receptors, LHRH - biosynthesis Receptors, LHRH - genetics RNA, Small Interfering - genetics Secretion Swine Swine - genetics Swine - growth & development Testes Testis - growth & development Testis - metabolism Testosterone Testosterone - blood Transgenics zygote Zygotes
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