Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development

ABSTRACT Low nephron endowment at birth has been associated with an increased risk for developing hypertension and chronic kidney disease. We demonstrated in an earlier study that conditional deletion of the microRNA (miRNA)‐processing enzyme Dicer from nephron progenitors results in premature deple...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2017-08, Vol.31 (8), p.3540-3554
Hauptverfasser:	Cerqueira, Débora M., Bodnar, Andrew J., Leng Phua, Yu, Freer, Rachel, Hemker, Shelby L., Walensky, Loren D., Hukriede, Neil A., Ho, Jacqueline
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Apoptosis Apoptosis - physiology Bcl-2-Like Protein 11 - genetics Bcl-2-Like Protein 11 - metabolism Bcl‐2L11 BIM protein Building management systems DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Dicer Dosage Embryo, Nonmammalian Gene Deletion Gene dosage Gene Dosage - physiology Gene Expression Regulation, Developmental - physiology HEK293 Cells Humans Hypertension Kidney - embryology Kidneys metanephros Mice Mice, Transgenic MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA nephrogenesis Nephrons - cytology Ribonuclease III - genetics Ribonuclease III - metabolism Ribonucleic acid RNA Rodents Stem Cells - cytology Survival Xenopus laevis - embryology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!