Lipid degradation promotes prostate cancer cell survival

Prostate cancer is the most common male cancer and androgen receptor (AR) is the major driver of the disease. Here we show that Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival. Increased ECI2 expression predicts mortality in prostate cancer patient...

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Veröffentlicht in:	Oncotarget 2017-06, Vol.8 (24), p.38264-38275
Hauptverfasser:	Itkonen, Harri M, Brown, Michael, Urbanucci, Alfonso, Tredwell, Gregory, Ho Lau, Chung, Barfeld, Stefan, Hart, Claire, Guldvik, Ingrid J, Takhar, Mandeep, Heemers, Hannelore V, Erho, Nicholas, Bloch, Katarzyna, Davicioni, Elai, Derua, Rita, Waelkens, Etienne, Mohler, James L, Clarke, Noel, Swinnen, Johan V, Keun, Hector C, Rekvig, Ole P, Mills, Ian G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Dodecenoyl-CoA Isomerase - metabolism Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Lipid Metabolism - drug effects Lipid Metabolism - physiology Male Perhexiline - pharmacology Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Research Paper
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