Phased diploid genome assembly with single-molecule real-time sequencing

The open-source FALCON and FALCON-Unzip software utilize long-read sequencing data to generate contiguous, accurate and phased diploid assemblies, even from genomes that are highly heterozygous. While genome assembly projects have been successful in many haploid and inbred species, the assembly of n...

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Veröffentlicht in:	Nature methods 2016-12, Vol.13 (12), p.1050-1054
Hauptverfasser:	Chin, Chen-Shan, Peluso, Paul, Sedlazeck, Fritz J, Nattestad, Maria, Concepcion, Gregory T, Clum, Alicia, Dunn, Christopher, O'Malley, Ronan, Figueroa-Balderas, Rosa, Morales-Cruz, Abraham, Cramer, Grant R, Delledonne, Massimo, Luo, Chongyuan, Ecker, Joseph R, Cantu, Dario, Rank, David R, Schatz, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2785/2302 631/61/514/1948 Algorithms Analysis Arabidopsis - genetics Arabidopsis thaliana Basidiomycota - genetics Bioinformatics Biological Microscopy Biological Techniques Biology Biomedical Engineering/Biotechnology Chromosomes Diploidy DNA sequencing DNA, Fungal - genetics DNA, Plant - genetics Genetic aspects Genome, Fungal - genetics Genome, Plant - genetics Genomes Genomics - methods Haplotypes Heterozygote Humans Life Sciences Polymorphism, Single Nucleotide - genetics Proteomics Sequence Analysis, DNA Vitis - genetics Vitis vinifera
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