Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation

Germ cell tumors and particularly seminomas reflect the epigenomic features of their parental primordial germ cells (PGCs), including genomic DNA hypomethylation and expression of pluripotent cell markers. Because the DNA hypomethylation might be a result of TET dioxygenase activity, we examined exp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular carcinogenesis 2017-08, Vol.56 (8), p.1837-1850
Hauptverfasser:	Benešová, Martina, Trejbalová, Kateřina, Kučerová, Dana, Vernerová, Zdenka, Hron, Tomáš, Szabó, Arpád, Amouroux, Rachel, Klézl, Petr, Hajkova, Petra, Hejnar, Jiří
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - analysis 5‐hydroxymethylcytosine 5‐methylcytosine Adult CpG islands Deoxyribonucleic acid Dioxygenase Dioxygenases - analysis Dioxygenases - genetics DNA DNA Methylation DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics Enzymatic activity Enzymes Gene Expression Regulation, Neoplastic germ cell tumor Germ cells Humans Isocitrate dehydrogenase Liquid chromatography Male Mass spectroscopy Mixed Function Oxygenases - analysis Mixed Function Oxygenases - genetics Pluripotency Polymerase chain reaction Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Seminoma Seminoma - genetics Seminoma - pathology Staining Testicular Neoplasms - genetics Testicular Neoplasms - pathology Testis - metabolism Testis - pathology TET1 Tumors Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!