Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria

A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and M. marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemical analyses,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-07, Vol.114 (27), p.7025-7030
Hauptverfasser:	Harris, Nicholas C., Sato, Michio, Herman, Nicolaus A., Twigg, Frederick, Cai, Wenlong, Liu, Joyce, Zhu, Xuejun, Downey, Jordan, Khalaf, Ryan, Martin, Joelle, Koshino, Hiroyuki, Zhang, Wenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria Actinobacteria - enzymology Actinobacteria - genetics Acylation Amino groups Bacteria Biological Sciences Biological Transport Biosynthesis Catalysis Chromatography Chromatography, Ion Exchange Enzymes Escherichia coli - enzymology Escherichia coli - genetics Fatty Acids - chemistry Gene clusters Gene Deletion Homology Iron Lipopeptides Lipopeptides - biosynthesis Lysine - chemistry Metal concentrations Metals Multigene Family Mutation Mycobacterium marinum Mycobacterium marinum - enzymology Mycobacterium marinum - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Oxidase Peptide Synthases - genetics Peptide Synthases - metabolism Peptides Protein Domains Proteins Ribosomes - chemistry Thioesterase Tuberculosis
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