One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis

Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (P...

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Veröffentlicht in:	Organic letters 2017-02, Vol.19 (3), p.540-543
Hauptverfasser:	Wang, Guojun, Chen, Jing, Zhu, Haining, Rohr, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl coenzyme A Anthracyclines - metabolism Anti-Bacterial Agents antibiotics biochemical pathways biosynthesis chemical reactions chemical structure malonyl coenzyme A mixing Molecular Structure Polyketide Synthases polyketides Streptomyces
Online-Zugang:	Volltext
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