Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction

Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, the prognosis of patients with chronic heart failure remains poor, emphasizing the need to identify additional pathophysiological fa...

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Veröffentlicht in:	The Journal of experimental medicine 2017-07, Vol.214 (7), p.1877-1888
Hauptverfasser:	Tsuda, Takuma, Takefuji, Mikito, Wettschureck, Nina, Kotani, Kazuhiko, Morimoto, Ryota, Okumura, Takahiro, Kaur, Harmandeep, Eguchi, Shunsuke, Sakaguchi, Teruhiro, Ishihama, Sohta, Kikuchi, Ryosuke, Unno, Kazumasa, Matsushita, Kunihiro, Ishikawa, Shizukiyo, Offermanns, Stefan, Murohara, Toyoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine monophosphate Aged Animals Beta blockers Blotting, Western Cardiomyocytes Cells, Cultured Corticotropin-releasing hormone Cyclic AMP Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Female Gene Expression Heart Heart diseases Heart failure Heart Failure - blood Heart Failure - metabolism Heart Failure - physiopathology Humans Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Patients Perfusion Prognosis Receptors, Corticotropin-Releasing Hormone - agonists Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Signaling Urocortin Urocortins - blood Urocortins - pharmacology Ventricle Ventricular Function, Left - drug effects
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