NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

The nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here, we demonstrate that NUP98 fusion proteins, including NUP98-HOXA9 (NHA9), NUP98-HOXD13 (NHD13), NUP98-NSD1, NUP98-PHF23, and NUP98-TOP1 physically interact with mixed lineage leukemia...

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Veröffentlicht in:	Cancer cell 2016-12, Vol.30 (6), p.863-878
Hauptverfasser:	Xu, Haiming, Valerio, Daria G., Eisold, Meghan E., Sinha, Amit, Koche, Richard P., Hu, Wenhuo, Chen, Chun-Wei, Chu, S. Haihua, Brien, Gerard L., Park, Christopher Y., Hsieh, James J., Ernst, Patricia, Armstrong, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Chromatin - metabolism Gene Expression Regulation, Neoplastic HEK293 Cells Histone-Lysine N-Methyltransferase - metabolism Homeodomain Proteins - genetics Hox gene Humans leukemia Leukemia - metabolism Mice mixed lineage leukemia 1 Myeloid-Lymphoid Leukemia Protein - metabolism non-specific lethal histone-modifying complexes Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism NUP98 fusion Oncogene Proteins, Fusion - metabolism Promoter Regions, Genetic Tumor Cells, Cultured
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