Body mass index adjustments to increase the validity of body fatness assessment in UK Black African and South Asian children

Background/Objectives: Body mass index (BMI) (weight per height 2 ) is the most widely used marker of childhood obesity and total body fatness (BF). However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK c...

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Veröffentlicht in:International Journal of Obesity 2017-07, Vol.41 (7), p.1048-1055
Hauptverfasser: Hudda, M T, Nightingale, C M, Donin, A S, Fewtrell, M S, Haroun, D, Lum, S, Williams, J E, Owen, C G, Rudnicka, A R, Wells, J C K, Cook, D G, Whincup, P H
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container_issue 7
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container_title International Journal of Obesity
container_volume 41
creator Hudda, M T
Nightingale, C M
Donin, A S
Fewtrell, M S
Haroun, D
Lum, S
Williams, J E
Owen, C G
Rudnicka, A R
Wells, J C K
Cook, D G
Whincup, P H
description Background/Objectives: Body mass index (BMI) (weight per height 2 ) is the most widely used marker of childhood obesity and total body fatness (BF). However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK children of Black African and South Asian origins so that adjusted BMI related to BF in the same way as for White European children. Methods: We used data from four recent UK studies that made deuterium dilution BF measurements in UK children of White European, South Asian and Black African origins. A height-standardized fat mass index (FMI) was derived to represent BF. Linear regression models were then fitted, separately for boys and girls, to quantify ethnic differences in BMI–FMI relationships and to provide ethnic-specific BMI adjustments. Results: We restricted analyses to 4–12 year olds, to whom a single consistent FMI (fat mass per height 5 ) could be applied. BMI consistently underestimated BF in South Asians, requiring positive BMI adjustments of +1.12 kg m − 2 (95% confidence interval (CI): 0.83, 1.41 kg m − 2 ; P
doi_str_mv 10.1038/ijo.2017.75
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However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK children of Black African and South Asian origins so that adjusted BMI related to BF in the same way as for White European children. Methods: We used data from four recent UK studies that made deuterium dilution BF measurements in UK children of White European, South Asian and Black African origins. A height-standardized fat mass index (FMI) was derived to represent BF. Linear regression models were then fitted, separately for boys and girls, to quantify ethnic differences in BMI–FMI relationships and to provide ethnic-specific BMI adjustments. Results: We restricted analyses to 4–12 year olds, to whom a single consistent FMI (fat mass per height 5 ) could be applied. BMI consistently underestimated BF in South Asians, requiring positive BMI adjustments of +1.12 kg m − 2 (95% confidence interval (CI): 0.83, 1.41 kg m − 2 ; P &lt;0.0001) for boys and +1.07 kg m − 2 (95% CI: 0.74, 1.39 kg m − 2 ; P &lt;0.0001) for girls of all age groups and FMI levels. BMI overestimated BF in Black Africans, requiring negative BMI adjustments for Black African children. However, these were complex because there were statistically significant interactions between Black African ethnicity and FMI ( P =0.004 boys; P =0.003 girls) and also between FMI and age group ( P &lt;0.0001 for boys and girls). BMI adjustments therefore varied by age group and FMI level (and indirectly BMI); the largest adjustments were in younger children with higher unadjusted BMI and the smallest in older children with lower unadjusted BMI. Conclusions: BMI underestimated BF in South Asians and overestimated BF in Black Africans. Ethnic-specific adjustments, increasing BMI in South Asians and reducing BMI in Black Africans, can improve the accuracy of BF assessment in these children.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2017.75</identifier><identifier>PMID: 28325931</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/699/1702/393 ; 692/700/139/2818 ; 692/700/2817 ; Adipose Tissue ; Adiposity - ethnology ; Age ; Asian people ; Asians ; Blacks ; Body fat ; Body mass ; Body Mass Index ; Child ; Child, Preschool ; Children ; Children &amp; youth ; Confidence intervals ; Deuterium ; Dilution ; Epidemiology ; Female ; Girls ; Health aspects ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Minority &amp; ethnic groups ; Original ; original-article ; Origins ; Pediatric Obesity - diagnosis ; Pediatric Obesity - prevention &amp; control ; Public Health ; Reference Standards ; Regression analysis ; Reproducibility of Results ; Statistical analysis ; United Kingdom</subject><ispartof>International Journal of Obesity, 2017-07, Vol.41 (7), p.1048-1055</ispartof><rights>The Author(s) 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2017</rights><rights>Copyright © 2017 The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-cb67b16e649eb177d195e7e74930cacc2a82d9d6b43b8db3e3869cd6c8ecc7423</citedby><cites>FETCH-LOGICAL-c544t-cb67b16e649eb177d195e7e74930cacc2a82d9d6b43b8db3e3869cd6c8ecc7423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2017.75$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2017.75$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28325931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudda, M T</creatorcontrib><creatorcontrib>Nightingale, C M</creatorcontrib><creatorcontrib>Donin, A S</creatorcontrib><creatorcontrib>Fewtrell, M S</creatorcontrib><creatorcontrib>Haroun, D</creatorcontrib><creatorcontrib>Lum, S</creatorcontrib><creatorcontrib>Williams, J E</creatorcontrib><creatorcontrib>Owen, C G</creatorcontrib><creatorcontrib>Rudnicka, A R</creatorcontrib><creatorcontrib>Wells, J C K</creatorcontrib><creatorcontrib>Cook, D G</creatorcontrib><creatorcontrib>Whincup, P H</creatorcontrib><title>Body mass index adjustments to increase the validity of body fatness assessment in UK Black African and South Asian children</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives: Body mass index (BMI) (weight per height 2 ) is the most widely used marker of childhood obesity and total body fatness (BF). However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK children of Black African and South Asian origins so that adjusted BMI related to BF in the same way as for White European children. Methods: We used data from four recent UK studies that made deuterium dilution BF measurements in UK children of White European, South Asian and Black African origins. A height-standardized fat mass index (FMI) was derived to represent BF. Linear regression models were then fitted, separately for boys and girls, to quantify ethnic differences in BMI–FMI relationships and to provide ethnic-specific BMI adjustments. Results: We restricted analyses to 4–12 year olds, to whom a single consistent FMI (fat mass per height 5 ) could be applied. BMI consistently underestimated BF in South Asians, requiring positive BMI adjustments of +1.12 kg m − 2 (95% confidence interval (CI): 0.83, 1.41 kg m − 2 ; P &lt;0.0001) for boys and +1.07 kg m − 2 (95% CI: 0.74, 1.39 kg m − 2 ; P &lt;0.0001) for girls of all age groups and FMI levels. BMI overestimated BF in Black Africans, requiring negative BMI adjustments for Black African children. However, these were complex because there were statistically significant interactions between Black African ethnicity and FMI ( P =0.004 boys; P =0.003 girls) and also between FMI and age group ( P &lt;0.0001 for boys and girls). BMI adjustments therefore varied by age group and FMI level (and indirectly BMI); the largest adjustments were in younger children with higher unadjusted BMI and the smallest in older children with lower unadjusted BMI. Conclusions: BMI underestimated BF in South Asians and overestimated BF in Black Africans. Ethnic-specific adjustments, increasing BMI in South Asians and reducing BMI in Black Africans, can improve the accuracy of BF assessment in these children.</description><subject>692/308/174</subject><subject>692/699/1702/393</subject><subject>692/700/139/2818</subject><subject>692/700/2817</subject><subject>Adipose Tissue</subject><subject>Adiposity - ethnology</subject><subject>Age</subject><subject>Asian people</subject><subject>Asians</subject><subject>Blacks</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children &amp; youth</subject><subject>Confidence intervals</subject><subject>Deuterium</subject><subject>Dilution</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Girls</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; 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However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK children of Black African and South Asian origins so that adjusted BMI related to BF in the same way as for White European children. Methods: We used data from four recent UK studies that made deuterium dilution BF measurements in UK children of White European, South Asian and Black African origins. A height-standardized fat mass index (FMI) was derived to represent BF. Linear regression models were then fitted, separately for boys and girls, to quantify ethnic differences in BMI–FMI relationships and to provide ethnic-specific BMI adjustments. Results: We restricted analyses to 4–12 year olds, to whom a single consistent FMI (fat mass per height 5 ) could be applied. BMI consistently underestimated BF in South Asians, requiring positive BMI adjustments of +1.12 kg m − 2 (95% confidence interval (CI): 0.83, 1.41 kg m − 2 ; P &lt;0.0001) for boys and +1.07 kg m − 2 (95% CI: 0.74, 1.39 kg m − 2 ; P &lt;0.0001) for girls of all age groups and FMI levels. BMI overestimated BF in Black Africans, requiring negative BMI adjustments for Black African children. However, these were complex because there were statistically significant interactions between Black African ethnicity and FMI ( P =0.004 boys; P =0.003 girls) and also between FMI and age group ( P &lt;0.0001 for boys and girls). BMI adjustments therefore varied by age group and FMI level (and indirectly BMI); the largest adjustments were in younger children with higher unadjusted BMI and the smallest in older children with lower unadjusted BMI. Conclusions: BMI underestimated BF in South Asians and overestimated BF in Black Africans. Ethnic-specific adjustments, increasing BMI in South Asians and reducing BMI in Black Africans, can improve the accuracy of BF assessment in these children.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28325931</pmid><doi>10.1038/ijo.2017.75</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects 692/308/174
692/699/1702/393
692/700/139/2818
692/700/2817
Adipose Tissue
Adiposity - ethnology
Age
Asian people
Asians
Blacks
Body fat
Body mass
Body Mass Index
Child
Child, Preschool
Children
Children & youth
Confidence intervals
Deuterium
Dilution
Epidemiology
Female
Girls
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Minority & ethnic groups
Original
original-article
Origins
Pediatric Obesity - diagnosis
Pediatric Obesity - prevention & control
Public Health
Reference Standards
Regression analysis
Reproducibility of Results
Statistical analysis
United Kingdom
title Body mass index adjustments to increase the validity of body fatness assessment in UK Black African and South Asian children
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