Statistical analysis of genetic interactions in Tn-Seq data

Tn-Seq is an experimental method for probing the functions of genes through construction of complex random transposon insertion libraries and quantification of each mutant's abundance using next-generation sequencing. An important emerging application of Tn-Seq is for identifying genetic intera...

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Veröffentlicht in:	Nucleic acids research 2017-06, Vol.45 (11), p.e93-e93
Hauptverfasser:	DeJesus, Michael A, Nambi, Subhalaxmi, Smith, Clare M, Baker, Richard E, Sassetti, Christopher M, Ioerger, Thomas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bacterial Proteins - genetics Bayes Theorem Data Interpretation, Statistical DNA Transposable Elements Epistasis, Genetic Gene Frequency Gene Knockout Techniques Gene Library Genes, Bacterial Methods Online Models, Genetic Monte Carlo Method Mutagenesis, Insertional Mycobacterium tuberculosis - genetics Sequence Analysis, DNA - methods
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