GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2

Lagging strand synthesis is mechanistically far more complicated than leading strand synthesis because it involves multistep processes and requires considerably more enzymes and protein factors. Due to this complexity, multiple fail-safe factors are required to ensure successful replication of the l...

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Veröffentlicht in:	Genetics (Austin) 2017-06, Vol.206 (2), p.829-842
Hauptverfasser:	Demin, Annie Albert, Lee, Miju, Lee, Chul-Hwan, Seo, Yeon-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Annealing Catalysis Catalytic activity Complexity Defects Deoxyribonucleic acid DNA DNA - genetics DNA damage DNA helicase DNA Helicases - genetics DNA repair DNA Replication - genetics Enzymes Epistasis Fragmentation Genes Genetics Glycogen Synthase Kinase 3 beta - genetics Histone deacetylase Histone Deacetylases - genetics Homology Inhibition Inhibitors Intracellular Signaling Peptides and Proteins - genetics Investigations Kinases Lethality Maturation Mutant Proteins - genetics Mutation Phosphorylation Protein-Serine-Threonine Kinases - genetics Proteins Rad52 protein Recombination Reductase Replication Repressor Proteins - genetics Ribonucleotide reductase Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Sin3 Histone Deacetylase and Corepressor Complex - genetics Synthesis Toxicity Transcription factors Yeast
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