Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
Background. Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. Aim. We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. Materials...
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| creator | Afrifa, Justice Gyedu, Desmond Ofori Gyamerah, Eric Essien-Baidoo, Samuel Mensah-Essilfie, Isaac |
| description | Background. Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. Aim. We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. Materials and Methods. A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. Results. Haemoglobin (HGB) (P |
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Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. Aim. We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. Materials and Methods. A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. Results. Haemoglobin (HGB) (P<0.0001), haematocrit (HCT) (P<0.0001), mean cell volume (MCV) (P=0.0053), mean cell haemoglobin (MCH) (P<0.0001), and mean cell haemoglobin concentration (MCHC) (P=0.005) levels were reduced in cases compared to controls. Mixed cell percentage (MXD) (P=0.018) and red blood cell distribution width (RDW-CV) (P=0.012) were significantly elevated among cases as compared to controls. Haematuria was a clinical characteristic of heavy infection. Conclusion. S. haematobium infection creates an imbalance in the haematological profile. We found low HGB, HCT, MCV, MCH, and MCHC levels coupled with increased % MXD count and RDW-CV. Also, low MCV, MCH, and MCHC and high % MXD count are independently associated with S. haematobium infection among our study participants.</description><identifier>ISSN: 1687-9805</identifier><identifier>EISSN: 1687-9813</identifier><identifier>DOI: 10.1155/2017/4248325</identifier><identifier>PMID: 28713432</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Adolescent ; Anemia ; Animals ; Blood ; Blood Chemical Analysis ; Case-Control Studies ; Child ; Female ; Ghana ; Health aspects ; Hematologic Tests ; Hematology ; Hemoglobin ; Humans ; Infections ; Laboratories ; Male ; Medical research ; Medicine, Experimental ; Parasite Egg Count ; Sample size ; Schistosoma haematobium - physiology ; Schistosomiasis ; Schistosomiasis haematobia - blood ; Schistosomiasis haematobia - parasitology ; Science education ; Studies ; Urine</subject><ispartof>Journal of environmental and public health, 2017-01, Vol.2017, p.4248325-5</ispartof><rights>Copyright © 2017 Justice Afrifa et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Justice Afrifa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Justice Afrifa et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-d68dacbd54f6ed88a6ec7e70487c81a657bf86f6812eeaf0f074f5e0957489aa3</citedby><cites>FETCH-LOGICAL-c476t-d68dacbd54f6ed88a6ec7e70487c81a657bf86f6812eeaf0f074f5e0957489aa3</cites><orcidid>0000-0002-8618-6648 ; 0000-0003-3399-2969</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497644/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497644/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28713432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jolly, Pauline E.</contributor><creatorcontrib>Afrifa, Justice</creatorcontrib><creatorcontrib>Gyedu, Desmond</creatorcontrib><creatorcontrib>Ofori Gyamerah, Eric</creatorcontrib><creatorcontrib>Essien-Baidoo, Samuel</creatorcontrib><creatorcontrib>Mensah-Essilfie, Isaac</creatorcontrib><title>Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children</title><title>Journal of environmental and public health</title><addtitle>J Environ Public Health</addtitle><description>Background. Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. Aim. We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. Materials and Methods. A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. Results. Haemoglobin (HGB) (P<0.0001), haematocrit (HCT) (P<0.0001), mean cell volume (MCV) (P=0.0053), mean cell haemoglobin (MCH) (P<0.0001), and mean cell haemoglobin concentration (MCHC) (P=0.005) levels were reduced in cases compared to controls. Mixed cell percentage (MXD) (P=0.018) and red blood cell distribution width (RDW-CV) (P=0.012) were significantly elevated among cases as compared to controls. Haematuria was a clinical characteristic of heavy infection. Conclusion. S. haematobium infection creates an imbalance in the haematological profile. We found low HGB, HCT, MCV, MCH, and MCHC levels coupled with increased % MXD count and RDW-CV. Also, low MCV, MCH, and MCHC and high % MXD count are independently associated with S. haematobium infection among our study participants.</description><subject>Adolescent</subject><subject>Anemia</subject><subject>Animals</subject><subject>Blood</subject><subject>Blood Chemical Analysis</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Female</subject><subject>Ghana</subject><subject>Health aspects</subject><subject>Hematologic Tests</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Parasite Egg Count</subject><subject>Sample size</subject><subject>Schistosoma haematobium - physiology</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis haematobia - blood</subject><subject>Schistosomiasis haematobia - parasitology</subject><subject>Science education</subject><subject>Studies</subject><subject>Urine</subject><issn>1687-9805</issn><issn>1687-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90c1rFDEYBvBBFFurN88y4EXQtUkmX3MRylLbQkFBi8fwbubNTkomqcms0v--WXZdqgdPCeTHk7x5muY1JR8pFeKUEapOOeO6Y-JJc0ylVote0-7pYU_EUfOilFtCZN8p9rw5YlrRjnfsuPlxCTjBnEJaewuh_ZqT8wFbiEN7FWeMxc_3bXLtTU5rjH6u5psdfZlTSZOH4kvrY3sxQgQPsV2OPgwZ48vmmYNQ8NV-PWluPp9_X14urr9cXC3PrheWKzkvBqkHsKtBcCdx0BokWoWKcK2spiCFWjktndSUIYIjjijuBJJeKK57gO6k-bTLvdusJhwsxjlDMHfZT5DvTQJv_j6JfjTr9MsI3ivJeQ14tw_I6ecGy2wmXyyGABHTphja1w_utepkpW__obdpk2MdryoqGJdKP1JrCGh8dKnea7eh5kxwxngnqKjqw07ZnErJ6A5PpsRsezXbXs2-18rfPB7zgP8UWcH7HRh9HOC3_3_cA_grqrU</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Afrifa, Justice</creator><creator>Gyedu, Desmond</creator><creator>Ofori Gyamerah, Eric</creator><creator>Essien-Baidoo, Samuel</creator><creator>Mensah-Essilfie, Isaac</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8618-6648</orcidid><orcidid>https://orcid.org/0000-0003-3399-2969</orcidid></search><sort><creationdate>20170101</creationdate><title>Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children</title><author>Afrifa, Justice ; Gyedu, Desmond ; Ofori Gyamerah, Eric ; Essien-Baidoo, Samuel ; Mensah-Essilfie, Isaac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-d68dacbd54f6ed88a6ec7e70487c81a657bf86f6812eeaf0f074f5e0957489aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Anemia</topic><topic>Animals</topic><topic>Blood</topic><topic>Blood Chemical Analysis</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Female</topic><topic>Ghana</topic><topic>Health aspects</topic><topic>Hematologic Tests</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Parasite Egg Count</topic><topic>Sample size</topic><topic>Schistosoma haematobium - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of environmental and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afrifa, Justice</au><au>Gyedu, Desmond</au><au>Ofori Gyamerah, Eric</au><au>Essien-Baidoo, Samuel</au><au>Mensah-Essilfie, Isaac</au><au>Jolly, Pauline E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children</atitle><jtitle>Journal of environmental and public health</jtitle><addtitle>J Environ Public Health</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><spage>4248325</spage><epage>5</epage><pages>4248325-5</pages><issn>1687-9805</issn><eissn>1687-9813</eissn><abstract>Background. Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. Aim. We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. Materials and Methods. A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. Results. Haemoglobin (HGB) (P<0.0001), haematocrit (HCT) (P<0.0001), mean cell volume (MCV) (P=0.0053), mean cell haemoglobin (MCH) (P<0.0001), and mean cell haemoglobin concentration (MCHC) (P=0.005) levels were reduced in cases compared to controls. Mixed cell percentage (MXD) (P=0.018) and red blood cell distribution width (RDW-CV) (P=0.012) were significantly elevated among cases as compared to controls. Haematuria was a clinical characteristic of heavy infection. Conclusion. S. haematobium infection creates an imbalance in the haematological profile. We found low HGB, HCT, MCV, MCH, and MCHC levels coupled with increased % MXD count and RDW-CV. Also, low MCV, MCH, and MCHC and high % MXD count are independently associated with S. haematobium infection among our study participants.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>28713432</pmid><doi>10.1155/2017/4248325</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8618-6648</orcidid><orcidid>https://orcid.org/0000-0003-3399-2969</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Anemia Animals Blood Blood Chemical Analysis Case-Control Studies Child Female Ghana Health aspects Hematologic Tests Hematology Hemoglobin Humans Infections Laboratories Male Medical research Medicine, Experimental Parasite Egg Count Sample size Schistosoma haematobium - physiology Schistosomiasis Schistosomiasis haematobia - blood Schistosomiasis haematobia - parasitology Science education Studies Urine |
| title | Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children |
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