Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice

Aims/Introduction Peroxisome proliferator‐activated receptor‐α (PPARα) is a therapeutic target for hyperlipidemia. K‐877 is a new selective PPARα modulator (SPPARMα) that activates PPARα transcriptional activity. The aim of the present study was to assess the effects of K‐877 on lipid metabolism in...

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Veröffentlicht in:	Journal of diabetes investigation 2017-07, Vol.8 (4), p.446-452
Hauptverfasser:	Takei, Kenta, Han, Song‐iee, Murayama, Yuki, Satoh, Aoi, Oikawa, Fusaka, Ohno, Hiroshi, Osaki, Yoshinori, Matsuzaka, Takashi, Sekiya, Motohiro, Iwasaki, Hitoshi, Yatoh, Shigeru, Yahagi, Naoya, Suzuki, Hiroaki, Yamada, Nobuhiro, Nakagawa, Yoshimi, Shimano, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoxazoles - pharmacology Butyrates - pharmacology Cell Line Choline Drug Evaluation, Preclinical Fatty liver Fenofibrate Fenofibrate - pharmacology Gene Expression - drug effects Hyperlipidemia Hypolipidemic Agents - pharmacology Lipid metabolism Lipid Metabolism - drug effects Lipids Liver - drug effects Liver - metabolism Liver diseases Male Metabolism Methionine Mice, Inbred C57BL Original Oxidation Peroxisome proliferator-activated receptors Peroxisome proliferator‐activated receptor‐α PPAR alpha - agonists Pyrimidines - pharmacology Rodents Selective peroxisome proliferator‐activated receptor‐α modulator Transcription X-Box Binding Protein 1 - metabolism
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