The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity

In preterm infants, soluble inflammatory mediators target lung mesenchymal cells, disrupting airway and alveolar morphogenesis. However, how mesenchymal cells respond directly to microbial stimuli remains poorly characterized. Our objective was to measure the genome-wide innate immune response in fe...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2017-06, Vol.312 (6), p.L861-L872
Hauptverfasser:	Medal, Rachel M, Im, Amanda M, Yamamoto, Yasutoshi, Lakhdari, Omar, Blackwell, Timothy S, Hoffman, Hal M, Sahoo, Debashis, Prince, Lawrence S
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alveoli Animals Bacteria Cell Communication - drug effects Cell Communication - genetics Cell Movement - drug effects Cell Movement - genetics Cells Chemokines Disruption Endotoxins Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Extracellular signal-regulated kinase Fetus - cytology Fetuses FOXO3 protein Gene expression Gene Expression Regulation, Developmental - drug effects Genomes Immune response Immune system Immunity, Innate - drug effects Immunity, Innate - genetics Infants Inflammation Innate immunity Kinases Leukocyte migration Lipopolysaccharides Lipopolysaccharides - pharmacology Lung - embryology Lungs Mesenchyme Mesoderm - cytology Mesoderm - drug effects Mesoderm - immunology Mice, Inbred C57BL Microorganisms Morphogenesis Protein expression Protein-tyrosine kinase Respiratory tract Signal Transduction - drug effects Signal Transduction - genetics Transcription Transcription factors Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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