Role of NADPH oxidase in host defense against aspergillosis
NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We...
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| Veröffentlicht in: | Medical mycology (Oxford) 2011-04, Vol.49 (S1), p.S144-S149 |
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| container_title | Medical mycology (Oxford) |
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| creator | Grimm, Melissa J. Robert Vethanayagam, R. Almyroudis, Nikolaos G. Lewandowski, David Rall, Nicole Blackwell, Timothy S. Segal, Brahm H. |
| description | NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are prone to developing inflammatory diseases such as inflammatory bowel disease, obstructive granulomata of the genitourinary tract, and hypersensitivity pneumonitis. Indeed, the NADPH oxidase plays an essential role in calibrating innate and T-cell responses to control the growth of inhaled fungi while protecting against excessive and injurious inflammation. Knowledge gained on the mechanisms by which NADPH oxidase kills fungi and regulates inflammation may lead to new therapeutics for CGD and will have broad relevance to understanding host-pathogen interactions between mammals and ubiquitous moulds to which we are continually exposed. |
| doi_str_mv | 10.3109/13693786.2010.487077 |
| format | Article |
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Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are prone to developing inflammatory diseases such as inflammatory bowel disease, obstructive granulomata of the genitourinary tract, and hypersensitivity pneumonitis. Indeed, the NADPH oxidase plays an essential role in calibrating innate and T-cell responses to control the growth of inhaled fungi while protecting against excessive and injurious inflammation. Knowledge gained on the mechanisms by which NADPH oxidase kills fungi and regulates inflammation may lead to new therapeutics for CGD and will have broad relevance to understanding host-pathogen interactions between mammals and ubiquitous moulds to which we are continually exposed.</description><identifier>ISSN: 1369-3786</identifier><identifier>EISSN: 1460-2709</identifier><identifier>DOI: 10.3109/13693786.2010.487077</identifier><identifier>PMID: 20560866</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>Animals ; Aspergillosis - enzymology ; Aspergillosis - immunology ; Aspergillosis - microbiology ; Aspergillosis - mortality ; Aspergillus - immunology ; Aspergillus - pathogenicity ; Granulomatous Disease, Chronic - complications ; Granulomatous Disease, Chronic - enzymology ; Host-Pathogen Interactions - immunology ; Humans ; Immunity, Innate ; Inflammation - enzymology ; Inflammation - etiology ; Inflammation - immunology ; Mice ; NADPH Oxidases - metabolism ; Neutrophils ; Phenotype ; Protein Isoforms - metabolism ; T-Lymphocytes - classification ; T-Lymphocytes - immunology</subject><ispartof>Medical mycology (Oxford), 2011-04, Vol.49 (S1), p.S144-S149</ispartof><rights>2011 ISHAM 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-9e4df0771d58ad98e9d8e09e77aabd4c9bfb1741e0cea226e772ce8b98d9cbff3</citedby><cites>FETCH-LOGICAL-c502t-9e4df0771d58ad98e9d8e09e77aabd4c9bfb1741e0cea226e772ce8b98d9cbff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20560866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grimm, Melissa J.</creatorcontrib><creatorcontrib>Robert Vethanayagam, R.</creatorcontrib><creatorcontrib>Almyroudis, Nikolaos G.</creatorcontrib><creatorcontrib>Lewandowski, David</creatorcontrib><creatorcontrib>Rall, Nicole</creatorcontrib><creatorcontrib>Blackwell, Timothy S.</creatorcontrib><creatorcontrib>Segal, Brahm H.</creatorcontrib><title>Role of NADPH oxidase in host defense against aspergillosis</title><title>Medical mycology (Oxford)</title><addtitle>Med Mycol</addtitle><description>NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are prone to developing inflammatory diseases such as inflammatory bowel disease, obstructive granulomata of the genitourinary tract, and hypersensitivity pneumonitis. Indeed, the NADPH oxidase plays an essential role in calibrating innate and T-cell responses to control the growth of inhaled fungi while protecting against excessive and injurious inflammation. Knowledge gained on the mechanisms by which NADPH oxidase kills fungi and regulates inflammation may lead to new therapeutics for CGD and will have broad relevance to understanding host-pathogen interactions between mammals and ubiquitous moulds to which we are continually exposed.</description><subject>Animals</subject><subject>Aspergillosis - enzymology</subject><subject>Aspergillosis - immunology</subject><subject>Aspergillosis - microbiology</subject><subject>Aspergillosis - mortality</subject><subject>Aspergillus - immunology</subject><subject>Aspergillus - pathogenicity</subject><subject>Granulomatous Disease, Chronic - complications</subject><subject>Granulomatous Disease, Chronic - enzymology</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Inflammation - enzymology</subject><subject>Inflammation - etiology</subject><subject>Inflammation - immunology</subject><subject>Mice</subject><subject>NADPH Oxidases - metabolism</subject><subject>Neutrophils</subject><subject>Phenotype</subject><subject>Protein Isoforms - metabolism</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - immunology</subject><issn>1369-3786</issn><issn>1460-2709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhkVZWdJu_6AU3_XKjSTLlkShELKtHZS2jO1ayNJRouJYqWSP7d9PIUlpb8qu9HGe8-roQeiM4MuKYDkjVSMrLppLivMVExxzfoSmhDW4pBzLD3mfkXLLTNBJSk8YEy5p9RFNKK4bLJpmiq5-hA6K4Ir7-ZfH2yL88VYnKHxfrEIaCgsO-nzWS-37fNZpA3Hpuy4knz6hY6e7BJ_36yn69e3rz8Vtefdw830xvytNjelQSmDW5eGIrYW2UoC0ArAEzrVuLTOydS3hjAA2oCltcoEaEK0UVprWueoUXe9yN2O7BmugH6Lu1Cb6tY5_VdBeva30fqWW4beqmWRS1DngYh8Qw_MIaVBrnwx0ne4hjEmJmlNJMasyyXakiSGlCO7lFYLVVrs6aFdb7WqnPbedv57wpengOQOzHRDGzf9G7j_texfiWq9Ad8PK6AjqKYyxz8LfD_gHZP2gKw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Grimm, Melissa J.</creator><creator>Robert Vethanayagam, R.</creator><creator>Almyroudis, Nikolaos G.</creator><creator>Lewandowski, David</creator><creator>Rall, Nicole</creator><creator>Blackwell, Timothy S.</creator><creator>Segal, Brahm H.</creator><general>Informa Healthcare</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Role of NADPH oxidase in host defense against aspergillosis</title><author>Grimm, Melissa J. ; Robert Vethanayagam, R. ; Almyroudis, Nikolaos G. ; Lewandowski, David ; Rall, Nicole ; Blackwell, Timothy S. ; Segal, Brahm H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-9e4df0771d58ad98e9d8e09e77aabd4c9bfb1741e0cea226e772ce8b98d9cbff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Aspergillosis - enzymology</topic><topic>Aspergillosis - immunology</topic><topic>Aspergillosis - microbiology</topic><topic>Aspergillosis - mortality</topic><topic>Aspergillus - immunology</topic><topic>Aspergillus - pathogenicity</topic><topic>Granulomatous Disease, Chronic - complications</topic><topic>Granulomatous Disease, Chronic - enzymology</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Inflammation - enzymology</topic><topic>Inflammation - etiology</topic><topic>Inflammation - immunology</topic><topic>Mice</topic><topic>NADPH Oxidases - metabolism</topic><topic>Neutrophils</topic><topic>Phenotype</topic><topic>Protein Isoforms - metabolism</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grimm, Melissa J.</creatorcontrib><creatorcontrib>Robert Vethanayagam, R.</creatorcontrib><creatorcontrib>Almyroudis, Nikolaos G.</creatorcontrib><creatorcontrib>Lewandowski, David</creatorcontrib><creatorcontrib>Rall, Nicole</creatorcontrib><creatorcontrib>Blackwell, Timothy S.</creatorcontrib><creatorcontrib>Segal, Brahm H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical mycology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grimm, Melissa J.</au><au>Robert Vethanayagam, R.</au><au>Almyroudis, Nikolaos G.</au><au>Lewandowski, David</au><au>Rall, Nicole</au><au>Blackwell, Timothy S.</au><au>Segal, Brahm H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of NADPH oxidase in host defense against aspergillosis</atitle><jtitle>Medical mycology (Oxford)</jtitle><addtitle>Med Mycol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>49</volume><issue>S1</issue><spage>S144</spage><epage>S149</epage><pages>S144-S149</pages><issn>1369-3786</issn><eissn>1460-2709</eissn><abstract>NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are prone to developing inflammatory diseases such as inflammatory bowel disease, obstructive granulomata of the genitourinary tract, and hypersensitivity pneumonitis. Indeed, the NADPH oxidase plays an essential role in calibrating innate and T-cell responses to control the growth of inhaled fungi while protecting against excessive and injurious inflammation. Knowledge gained on the mechanisms by which NADPH oxidase kills fungi and regulates inflammation may lead to new therapeutics for CGD and will have broad relevance to understanding host-pathogen interactions between mammals and ubiquitous moulds to which we are continually exposed.</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>20560866</pmid><doi>10.3109/13693786.2010.487077</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Aspergillosis - enzymology Aspergillosis - immunology Aspergillosis - microbiology Aspergillosis - mortality Aspergillus - immunology Aspergillus - pathogenicity Granulomatous Disease, Chronic - complications Granulomatous Disease, Chronic - enzymology Host-Pathogen Interactions - immunology Humans Immunity, Innate Inflammation - enzymology Inflammation - etiology Inflammation - immunology Mice NADPH Oxidases - metabolism Neutrophils Phenotype Protein Isoforms - metabolism T-Lymphocytes - classification T-Lymphocytes - immunology |
| title | Role of NADPH oxidase in host defense against aspergillosis |
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