FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

FGF21 is an endocrine hormone that regulates energy homeostasis and insulin sensitivity. The mechanism of FGF21 action and the tissues responsible for these effects have been controversial, with both adipose tissues and the central nervous system having been identified as the target site mediating F...

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Veröffentlicht in:	Cell metabolism 2017-04, Vol.25 (4), p.935-944.e4
Hauptverfasser:	BonDurant, Lucas D., Ameka, Magdalene, Naber, Meghan C., Markan, Kathleen R., Idiga, Sharon O., Acevedo, Michael R., Walsh, Susan A., Ornitz, David M., Potthoff, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, Brown - metabolism adiponectin Adiponectin - metabolism adipose Adipose Tissue - metabolism Animals betaklotho brown Energy Metabolism FGF21 Fibroblast Growth Factors - metabolism glucose homeostasis insulin Insulin - metabolism Mice, Inbred C57BL Mice, Knockout sensitivity Signal Transduction Weight Loss white
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