PAR‐1 promotes microtubule breakdown during dendrite pruning in Drosophila

Pruning of unspecific neurites is an important mechanism during neuronal morphogenesis. Drosophila sensory neurons prune their dendrites during metamorphosis. Pruning dendrites are severed in their proximal regions. Prior to severing, dendritic microtubules undergo local disassembly, and dendrites t...

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Veröffentlicht in:	The EMBO journal 2017-07, Vol.36 (13), p.1981-1991
Hauptverfasser:	Herzmann, Svende, Krumkamp, Rafael, Rode, Sandra, Kintrup, Carina, Rumpf, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Breakdown Cascades Collapse Defects dendrite Dendrites Dendritic structure Destabilization Dismantling Drosophila Drosophila - physiology Drosophila Proteins - metabolism EMBO05 EMBO27 Endocytosis Epistasis Epistasis, Genetic Genetic analysis Glycogen Synthase Kinase 3 - metabolism Homology Insects Kinases Metamorphosis Microtubules Microtubules - metabolism Morphogenesis Neuronal Plasticity Neurons PAR‐1 Proteinase-activated receptor 1 Pruning Sensory neurons Signal Transduction Tau Tau protein Thinning
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