Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

The endosomal sorting complex required for transport (ESCRT)-III mediates membrane fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form persistent filaments that over time increase their curvature to constrict membranes. Unexpectedly, we found that ESCRT-III...

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Veröffentlicht in:	Nature cell biology 2017-07, Vol.19 (7), p.787-798
Hauptverfasser:	Mierzwa, Beata E., Chiaruttini, Nicolas, Redondo-Morata, Lorena, Moser von Filseck, Joachim, König, Julia, Larios, Jorge, Poser, Ina, Müller-Reichert, Thomas, Scheuring, Simon, Roux, Aurélien, Gerlich, Daniel W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/51 13/89 14/19 14/28 14/3 14/34 14/35 631/1647/328 631/80/313/2155 631/80/641/2090 82/62 82/83 Addition polymerization Adenosine triphosphatase Analysis Assemblies Assembly Atomic force microscopy ATPases Associated with Diverse Cellular Activities Cancer Research Cell Biology Cell membranes Cellular Biology Constrictions Curvature Cytokinesis Developmental Biology Endosomal Sorting Complexes Required for Transport - genetics Endosomal Sorting Complexes Required for Transport - metabolism Endosomes - enzymology Endosomes - ultrastructure Filaments HeLa Cells High speed Humans In vitro methods and tests Intracellular Membranes - enzymology Intracellular Membranes - ultrastructure Life Sciences Membranes Microscopy, Atomic Force Physiological aspects Polymerization RNA Interference Signal Transduction Spirals Stem Cells Time Factors Transfection Transport proteins Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism
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