Sam68 is absolutely required for Rev function and HIV-1 production

Sam68 functionally complements for, as well as synergizes with, HIV-1 Rev in Rev response element (RRE)-mediated gene expression and virus production. Furthermore, C-terminal deletion/point mutants of Sam68 (Sam68ΔC/Sam68-P21) exert a transdominant negative phenotype for Rev function and HIV-1 produ...

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Veröffentlicht in:	Nucleic acids research 2005-01, Vol.33 (3), p.873-879
Hauptverfasser:	Modem, Suhasini, Badri, Kameswara R., Holland, Thomas C., Reddy, Thipparthi R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Cell Line DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Expression Regulation, Viral Gene Products, rev - metabolism Genes, Reporter HeLa Cells HIV-1 - genetics HIV-1 - physiology Humans Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - physiology Response Elements rev Gene Products, Human Immunodeficiency Virus RNA Interference RNA Transport RNA, Messenger - metabolism RNA, Viral - chemistry RNA, Viral - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Transcriptional Activation
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