Altered regulatory T‐cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Altered regulatory T‐cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n...

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Veröffentlicht in:Clinical & translational immunology 2017-05, Vol.6 (5), p.e143-n/a
Hauptverfasser: Jones, Anderson P, Trend, Stephanie, Byrne, Scott N, Fabis‐Pedrini, Marzena J, Geldenhuys, Sian, Nolan, David, Booth, David R, Carroll, William M, Lucas, Robyn M, Kermode, Allan G, Hart, Prue H
Format: Artikel
Sprache:eng
Schlagworte:
CD27 antigen
CD45RA antigen
Cytokines
Genotype & phenotype
Helper cells
Immunoglobulin D
Immunology
Leukocytes (mononuclear)
Lymphocytes
Lymphocytes B
Lymphocytes T
Multiple sclerosis
Nervous system
Original
Peripheral blood mononuclear cells
Phenotypes
Studies
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Zusammenfassung:Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment‐naive individuals with recently diagnosed CIS (
ISSN:2050-0068
2050-0068
DOI:10.1038/cti.2017.18