Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation

Synaptic refinement is a critical step in nervous system maturation, requiring a carefully timed reorganization and refinement of neuronal connections. We have identified myrf-1 and myrf-2, two C. elegans homologs of Myrf family transcription factors, as key regulators of synaptic rewiring. MYRF-1 a...

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Veröffentlicht in:	Developmental cell 2017-04, Vol.41 (2), p.180-194.e7
Hauptverfasser:	Meng, Jun, Ma, Xiaoxia, Tao, Huaping, Jin, Xia, Witvliet, Daniel, Mitchell, James, Zhu, Ming, Dong, Meng-Qiu, Zhen, Mei, Jin, Yishi, Qi, Yingchuan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Caenorhabditis elegans Caenorhabditis elegans Proteins - economics Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Nucleus - metabolism critical period Endoplasmic Reticulum - metabolism ER localization ER to nuclear translocation GABAergic motor neuron intramolecular chaperone of endosialidase larval development Membrane Proteins - metabolism Neuronal Plasticity - genetics proteolytic cleavage synapse refinement Synapses - metabolism synaptic rewiring Transcription Factors - metabolism
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