CD99-Derived Agonist Ligands Inhibit Fibronectin-Induced Activation of β1 Integrin through the Protein Kinase A/SHP2/Extracellular Signal-Regulated Kinase/PTPN12/Focal Adhesion Kinase Signaling Pathway

The human CD99 protein is a 32-kDa glycosylated transmembrane protein that regulates various cellular responses, including cell adhesion and leukocyte extravasation. We previously reported that CD99 activation suppresses β1 integrin activity through dephosphorylation of focal adhesion kinase (FAK) a...

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Veröffentlicht in:	Molecular and cellular biology 2017-07, Vol.37 (14)
Hauptverfasser:	Lee, Kyoung-Jin, Kim, Yuri, Yoo, Yeon Ho, Kim, Min-Seo, Lee, Sun-Hee, Kim, Chang-Gyum, Park, Kyeonghan, Jeoung, Dooil, Lee, Hansoo, Ko, In Young, Hahn, Jang-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen - metabolism agonist ligands CD99 Cell Adhesion - physiology Cell Line, Tumor Cell Movement - physiology Cyclic AMP-Dependent Protein Kinases - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Fibronectins - metabolism Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Integrin beta Chains - metabolism Ligands MCF-7 cells Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 12 - metabolism PTPN12 Signal Transduction - physiology β1 integrin
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