Recent translational research: microarray expression profiling of breast cancer--beyond classification and prognostic markers?
Genomic expression profiling has greatly improved our ability to subclassify human breast cancers according to shared molecular characteristics and clinical behavior. The logical next question is whether this technology will be similarly useful for identifying the dominant signaling pathways that dr...
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| Veröffentlicht in: | Breast cancer research : BCR 2004-01, Vol.6 (5), p.192-200, Article 192 |
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| container_title | Breast cancer research : BCR |
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| creator | Wilson, Cindy A Dering, Judy |
| description | Genomic expression profiling has greatly improved our ability to subclassify human breast cancers according to shared molecular characteristics and clinical behavior. The logical next question is whether this technology will be similarly useful for identifying the dominant signaling pathways that drive tumor initiation and progression within each breast cancer subtype. A major challenge will be to integrate data generated from the experimental manipulation of model systems with expression profiles obtained from primary tumors. We highlight some recent progress and discuss several obstacles in the use of expression profiling to identify pathway signatures in human breast cancer. |
| doi_str_mv | 10.1186/bcr917 |
| format | Article |
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We highlight some recent progress and discuss several obstacles in the use of expression profiling to identify pathway signatures in human breast cancer.</description><subject>Analysis</subject><subject>Animals</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Development and progression</subject><subject>Estrogen</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology, Experimental</subject><subject>Prognosis</subject><subject>Receptors, Estrogen</subject><subject>Signal Transduction</subject><issn>1465-542X</issn><issn>1465-5411</issn><issn>1465-542X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Ul1LHDEUDaVSP9r-hBL60LfRZDIzyQgiIrYVhEKp4FtIMjdrbCZZk9nivvjbm-0uXRUkDwn3nnPPvfcEoY-UHFIquiNtUk_5G7RHm66t2qa-efvkvYv2c74jhHLRindol7aMir5u9tDjTzAQJjwlFbJXk4tBeZwgg0rm9hiPzqSoUlJLDA_zEs8FgecpWuddmOFosU6g8oSNCgZSVWlYxjBg41XBWmf-1cSqhAprFmKenMGjSr8h5dP3aMcqn-HD5j5A118vfp1_r65-fLs8P7uqdMP5VLGGa2HaGjQxph8srxsNghsQQ080GXiveU-ADMTWwGxLgXcDo9RaahgQxg7QybrufKFHGFYjJ-XlPLnSyVJG5eTzTHC3chb_yLYpaxWF36_52sVX-M8zJo5y7Unhftlop3i_gDzJ0WUD3qsAcZFl1wnCOrES-fwCeBcXqfiRZc06Urzjq0kO16CZ8iBdsLHomXIGKF7FAMUYkGeNIB3pGWm38sXInBPY_11TIld_Z9vnp6c72sI2n4X9BcCaxX8</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Wilson, Cindy A</creator><creator>Dering, Judy</creator><general>BioMed Central Ltd</general><general>National Library of Medicine - MEDLINE Abstracts</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040101</creationdate><title>Recent translational research: microarray expression profiling of breast cancer--beyond classification and prognostic markers?</title><author>Wilson, Cindy A ; Dering, Judy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-347b8c52eb0cc9df724be87ce8d90b0d79b790e0d0f2e3f51e76d311ff1c3e033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Development and progression</topic><topic>Estrogen</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncology, Experimental</topic><topic>Prognosis</topic><topic>Receptors, Estrogen</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Cindy A</creatorcontrib><creatorcontrib>Dering, Judy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research : BCR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Cindy A</au><au>Dering, Judy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent translational research: microarray expression profiling of breast cancer--beyond classification and prognostic markers?</atitle><jtitle>Breast cancer research : BCR</jtitle><addtitle>Breast Cancer Res</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>6</volume><issue>5</issue><spage>192</spage><epage>200</epage><pages>192-200</pages><artnum>192</artnum><issn>1465-542X</issn><issn>1465-5411</issn><eissn>1465-542X</eissn><abstract>Genomic expression profiling has greatly improved our ability to subclassify human breast cancers according to shared molecular characteristics and clinical behavior. 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| ispartof | Breast cancer research : BCR, 2004-01, Vol.6 (5), p.192-200, Article 192 |
| issn | 1465-542X 1465-5411 1465-542X |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Analysis Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell Line, Tumor Development and progression Estrogen Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis Oncology, Experimental Prognosis Receptors, Estrogen Signal Transduction |
| title | Recent translational research: microarray expression profiling of breast cancer--beyond classification and prognostic markers? |
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