Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials
BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATE...
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| Veröffentlicht in: | Medical science monitor 2017-06, Vol.23, p.3044-3053 |
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| description | BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level. RESULTS A total of 12 studies (684 patients) were entered into the final analysis. The effect of probiotics was significant on reducing HbA1c level (standardized mean difference [SMD], -0.38; confidence interval [CI], -0.62 to -0.14, P=0.002; I²=0%, P=0.72 for heterogeneity), fasting insulin level (SMD, -0.38; CI -0.59 to -0.18, P=0.0003; I²=0%, P=0.81 for heterogeneity), and HOMA-IR (SMD, -0.99; CI -1.52 to -0.47, P=0.0002; I²=86%, P |
| doi_str_mv | 10.12659/MSM.902600 |
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This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level. RESULTS A total of 12 studies (684 patients) were entered into the final analysis. The effect of probiotics was significant on reducing HbA1c level (standardized mean difference [SMD], -0.38; confidence interval [CI], -0.62 to -0.14, P=0.002; I²=0%, P=0.72 for heterogeneity), fasting insulin level (SMD, -0.38; CI -0.59 to -0.18, P=0.0003; I²=0%, P=0.81 for heterogeneity), and HOMA-IR (SMD, -0.99; CI -1.52 to -0.47, P=0.0002; I²=86%, P<0.00001 for heterogeneity). Pooled results on effects of probiotics on FPG, CRP, or lipid profile were either non-significant or highly heterogeneous. CONCLUSIONS This meta-analysis demonstrated that probiotics supplementation was associated with significant improvement in HbA1c and fasting insulin in type 2 diabetes patients. More randomized placebo-controlled trials with large sample sizes are warranted to confirm our conclusions.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.902600</identifier><identifier>PMID: 28638006</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Blood Glucose - metabolism ; C-Reactive Protein - metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Humans ; Lipid Metabolism - drug effects ; Lipids - blood ; Meta-Analysis ; Probiotics - pharmacology ; Probiotics - therapeutic use ; Publication Bias ; Randomized Controlled Trials as Topic ; Risk Factors</subject><ispartof>Medical science monitor, 2017-06, Vol.23, p.3044-3053</ispartof><rights>Med Sci Monit, 2017 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-53707b2357707df50bdea4eabf5156d3e628a1e5ce733b7b26c0bda0102f39cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491138/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491138/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28638006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Kecheng</creatorcontrib><creatorcontrib>Zeng, Linghai</creatorcontrib><creatorcontrib>He, Qian</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Lei, Jiao</creatorcontrib><creatorcontrib>Zou, Xiulan</creatorcontrib><title>Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level. RESULTS A total of 12 studies (684 patients) were entered into the final analysis. The effect of probiotics was significant on reducing HbA1c level (standardized mean difference [SMD], -0.38; confidence interval [CI], -0.62 to -0.14, P=0.002; I²=0%, P=0.72 for heterogeneity), fasting insulin level (SMD, -0.38; CI -0.59 to -0.18, P=0.0003; I²=0%, P=0.81 for heterogeneity), and HOMA-IR (SMD, -0.99; CI -1.52 to -0.47, P=0.0002; I²=86%, P<0.00001 for heterogeneity). Pooled results on effects of probiotics on FPG, CRP, or lipid profile were either non-significant or highly heterogeneous. CONCLUSIONS This meta-analysis demonstrated that probiotics supplementation was associated with significant improvement in HbA1c and fasting insulin in type 2 diabetes patients. More randomized placebo-controlled trials with large sample sizes are warranted to confirm our conclusions.</description><subject>Blood Glucose - metabolism</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Humans</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>Meta-Analysis</subject><subject>Probiotics - pharmacology</subject><subject>Probiotics - therapeutic use</subject><subject>Publication Bias</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Factors</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLAzEURoMoWqsr95KlIKN5TObhQij1CS2K1nXIZO5oJDOpkxmhrv3hxraKrr4L9_DlhoPQASUnlCUiP50-Tk9ywhJCNtCAJjGPeCrI5p95B-16_0oIyxIittFOSJ4RkgzQ52VVge6wq_B96wrjOqM9dg2-tr12HrBqSjwxc1PiKXSqcNb4GpsGzxZzwAxfGFVABz5srTVd78_waElGo0bZhTf-u5oy_BCKXG0-oMRj13StszaMs9Yo6_fQVhUC9tc5RE9Xl7PxTTS5u74djyaRjhnvIsFTkhaMizRkWQlSlKBiUEUlqEhKDgnLFAWhIeW8CGSiA6IIJaziuS75EJ2veud9UUOpIdyhrJy3plbtQjpl5P9NY17ks3uXIs4p5VkoOFoXtO6tB9_J2ngdfq4acL2XNA9GKBVZHNDjFapb530L1e8zlMilNxm8yZW3QB_-veyX_RHFvwCn4ZRI</recordid><startdate>20170622</startdate><enddate>20170622</enddate><creator>Yao, Kecheng</creator><creator>Zeng, Linghai</creator><creator>He, Qian</creator><creator>Wang, Wei</creator><creator>Lei, Jiao</creator><creator>Zou, Xiulan</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170622</creationdate><title>Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials</title><author>Yao, Kecheng ; Zeng, Linghai ; He, Qian ; Wang, Wei ; Lei, Jiao ; Zou, Xiulan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-53707b2357707df50bdea4eabf5156d3e628a1e5ce733b7b26c0bda0102f39cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood Glucose - metabolism</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Humans</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids - blood</topic><topic>Meta-Analysis</topic><topic>Probiotics - pharmacology</topic><topic>Probiotics - therapeutic use</topic><topic>Publication Bias</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Yao, Kecheng</creatorcontrib><creatorcontrib>Zeng, Linghai</creatorcontrib><creatorcontrib>He, Qian</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Lei, Jiao</creatorcontrib><creatorcontrib>Zou, Xiulan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Kecheng</au><au>Zeng, Linghai</au><au>He, Qian</au><au>Wang, Wei</au><au>Lei, Jiao</au><au>Zou, Xiulan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2017-06-22</date><risdate>2017</risdate><volume>23</volume><spage>3044</spage><epage>3053</epage><pages>3044-3053</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level. RESULTS A total of 12 studies (684 patients) were entered into the final analysis. The effect of probiotics was significant on reducing HbA1c level (standardized mean difference [SMD], -0.38; confidence interval [CI], -0.62 to -0.14, P=0.002; I²=0%, P=0.72 for heterogeneity), fasting insulin level (SMD, -0.38; CI -0.59 to -0.18, P=0.0003; I²=0%, P=0.81 for heterogeneity), and HOMA-IR (SMD, -0.99; CI -1.52 to -0.47, P=0.0002; I²=86%, P<0.00001 for heterogeneity). Pooled results on effects of probiotics on FPG, CRP, or lipid profile were either non-significant or highly heterogeneous. CONCLUSIONS This meta-analysis demonstrated that probiotics supplementation was associated with significant improvement in HbA1c and fasting insulin in type 2 diabetes patients. More randomized placebo-controlled trials with large sample sizes are warranted to confirm our conclusions.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>28638006</pmid><doi>10.12659/MSM.902600</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood Glucose - metabolism C-Reactive Protein - metabolism Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Humans Lipid Metabolism - drug effects Lipids - blood Meta-Analysis Probiotics - pharmacology Probiotics - therapeutic use Publication Bias Randomized Controlled Trials as Topic Risk Factors |
| title | Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials |
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