RASA1 regulates the function of lymphatic vessel valves in mice

Capillary malformation-arteriovenous malformation (CM-AVM) is a blood and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulator of the Ras small GTP-binding protein. How RASA1 mutations lead to the...

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Veröffentlicht in:	The Journal of clinical investigation 2017-07, Vol.127 (7), p.2569-2585
Hauptverfasser:	Lapinski, Philip E, Lubeck, Beth A, Chen, Di, Doosti, Abbas, Zawieja, Scott D, Davis, Michael J, King, Philip D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical research Cooperation Defects Embryos Endothelial cells Endothelial Cells - metabolism Gene mutation GTP-binding protein Leakage Lymphatic Vessels - metabolism Lymphedema Mice Mice, Mutant Strains Morphogenesis Mutation Mutation, Missense p120 GTPase Activating Protein - genetics p120 GTPase Activating Protein - metabolism Pathogenesis Protein binding Proteins Ras protein Rodents Shear stress Signal transduction Valves
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