Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis
The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between leve...
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| Veröffentlicht in: | Nutrients 2017-05, Vol.9 (6), p.532 |
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| creator | Munblit, Daniel Treneva, Marina Peroni, Diego G Colicino, Silvia Chow, Li Yan Dissanayeke, Shobana Pampura, Alexander Boner, Attilio L Geddes, Donna T Boyle, Robert J Warner, John O |
| description | The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules. Statistical analyses used models adjusting for the site of collection, colostrum collection time, parity and maternal atopic status. Preliminary univariate analysis showed detectable interleukin (IL) 2 and IL13 in HM to be associated with less eczema. This finding was further confirmed in multivariate analysis, with detectable HM IL13 showing protective effect OR 0.18 (95% CI 0.04-0.92). In contrast, a higher risk of eczema was associated with higher HM concentrations of transforming growth factor β (TGFβ) 2 OR 1.04 (95% CI 1.01-1.06) per ng/mL. Parental-reported food allergy was reported less often when IL13 was detectable in colostrum OR 0.10 (95% CI 0.01-0.83). HM hepatocyte growth factor (HGF) was protective for common cold incidence at 12 months OR 0.19 (95% CI 0.04-0.92) per ng/mL. Data from this study suggests that differences in the individual immune composition of HM may have an influence on early life infant health outcomes. Increased TGFβ2 levels in HM are associated with a higher incidence of reported eczema, with detectable IL13 in colostrum showing protective effects for food allergy and sensitization. HGF shows some protective effect on common cold incidence at one year of age. Future studies should be focused on maternal genotype, human milk microbiome and diet influence on human milk immune composition and both short- and long-term health outcomes in the infant. |
| doi_str_mv | 10.3390/nu9060532 |
| format | Article |
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Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules. Statistical analyses used models adjusting for the site of collection, colostrum collection time, parity and maternal atopic status. Preliminary univariate analysis showed detectable interleukin (IL) 2 and IL13 in HM to be associated with less eczema. This finding was further confirmed in multivariate analysis, with detectable HM IL13 showing protective effect OR 0.18 (95% CI 0.04-0.92). In contrast, a higher risk of eczema was associated with higher HM concentrations of transforming growth factor β (TGFβ) 2 OR 1.04 (95% CI 1.01-1.06) per ng/mL. Parental-reported food allergy was reported less often when IL13 was detectable in colostrum OR 0.10 (95% CI 0.01-0.83). HM hepatocyte growth factor (HGF) was protective for common cold incidence at 12 months OR 0.19 (95% CI 0.04-0.92) per ng/mL. Data from this study suggests that differences in the individual immune composition of HM may have an influence on early life infant health outcomes. Increased TGFβ2 levels in HM are associated with a higher incidence of reported eczema, with detectable IL13 in colostrum showing protective effects for food allergy and sensitization. HGF shows some protective effect on common cold incidence at one year of age. Future studies should be focused on maternal genotype, human milk microbiome and diet influence on human milk immune composition and both short- and long-term health outcomes in the infant.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9060532</identifier><identifier>PMID: 28538696</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Atopy ; Baby foods ; Breast feeding ; Breast milk ; childhood ; Children ; Colostrum ; Colostrum - chemistry ; Colostrum - immunology ; Common cold ; Composition ; diet ; Eczema ; Eczema - epidemiology ; Eczema - immunology ; Eczema - prevention & control ; Female ; Follow-Up Studies ; Food allergies ; genotype ; Genotypes ; Growth factors ; Health ; Hepatocyte growth factor ; Hepatocyte Growth Factor - analysis ; Humans ; Hypersensitivity, Immediate - epidemiology ; Hypersensitivity, Immediate - immunology ; Hypersensitivity, Immediate - prevention & control ; Immunology ; Incidence ; Infant ; Interleukin 1 ; Interleukin 13 ; Interleukin-13 - analysis ; interleukin-2 ; Interleukin-2 - analysis ; Italy ; lactating women ; Lactation ; Male ; Mathematical models ; Maturation ; microbiome ; Microbiomes ; Milk ; Milk, Human - chemistry ; Milk, Human - immunology ; Molecular modelling ; Multivariate analysis ; Pregnancy ; Prevalence ; Prospective Studies ; protective effect ; risk ; Russia ; Skin diseases ; Statistical analysis ; Statistical methods ; Surveys and Questionnaires ; Transforming growth factor ; transforming growth factor beta ; Transforming Growth Factor beta2 - analysis ; Transforming growth factor-b ; United Kingdom</subject><ispartof>Nutrients, 2017-05, Vol.9 (6), p.532</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-fc0da440698816134a01cd08c41a3be0c7c2f4b3260a1738aa8dc3d72f88e6b63</citedby><cites>FETCH-LOGICAL-c436t-fc0da440698816134a01cd08c41a3be0c7c2f4b3260a1738aa8dc3d72f88e6b63</cites><orcidid>0000-0001-9652-6856 ; 0000-0002-4913-7580 ; 0000-0002-0234-1373 ; 0000-0002-0262-6280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490511/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490511/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28538696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munblit, Daniel</creatorcontrib><creatorcontrib>Treneva, Marina</creatorcontrib><creatorcontrib>Peroni, Diego G</creatorcontrib><creatorcontrib>Colicino, Silvia</creatorcontrib><creatorcontrib>Chow, Li Yan</creatorcontrib><creatorcontrib>Dissanayeke, Shobana</creatorcontrib><creatorcontrib>Pampura, Alexander</creatorcontrib><creatorcontrib>Boner, Attilio L</creatorcontrib><creatorcontrib>Geddes, Donna T</creatorcontrib><creatorcontrib>Boyle, Robert J</creatorcontrib><creatorcontrib>Warner, John O</creatorcontrib><title>Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules. Statistical analyses used models adjusting for the site of collection, colostrum collection time, parity and maternal atopic status. Preliminary univariate analysis showed detectable interleukin (IL) 2 and IL13 in HM to be associated with less eczema. This finding was further confirmed in multivariate analysis, with detectable HM IL13 showing protective effect OR 0.18 (95% CI 0.04-0.92). In contrast, a higher risk of eczema was associated with higher HM concentrations of transforming growth factor β (TGFβ) 2 OR 1.04 (95% CI 1.01-1.06) per ng/mL. Parental-reported food allergy was reported less often when IL13 was detectable in colostrum OR 0.10 (95% CI 0.01-0.83). HM hepatocyte growth factor (HGF) was protective for common cold incidence at 12 months OR 0.19 (95% CI 0.04-0.92) per ng/mL. Data from this study suggests that differences in the individual immune composition of HM may have an influence on early life infant health outcomes. Increased TGFβ2 levels in HM are associated with a higher incidence of reported eczema, with detectable IL13 in colostrum showing protective effects for food allergy and sensitization. HGF shows some protective effect on common cold incidence at one year of age. Future studies should be focused on maternal genotype, human milk microbiome and diet influence on human milk immune composition and both short- and long-term health outcomes in the infant.</description><subject>Atopy</subject><subject>Baby foods</subject><subject>Breast feeding</subject><subject>Breast milk</subject><subject>childhood</subject><subject>Children</subject><subject>Colostrum</subject><subject>Colostrum - chemistry</subject><subject>Colostrum - immunology</subject><subject>Common cold</subject><subject>Composition</subject><subject>diet</subject><subject>Eczema</subject><subject>Eczema - epidemiology</subject><subject>Eczema - immunology</subject><subject>Eczema - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Food allergies</subject><subject>genotype</subject><subject>Genotypes</subject><subject>Growth factors</subject><subject>Health</subject><subject>Hepatocyte growth factor</subject><subject>Hepatocyte Growth Factor - analysis</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Hypersensitivity, Immediate - prevention & control</subject><subject>Immunology</subject><subject>Incidence</subject><subject>Infant</subject><subject>Interleukin 1</subject><subject>Interleukin 13</subject><subject>Interleukin-13 - analysis</subject><subject>interleukin-2</subject><subject>Interleukin-2 - analysis</subject><subject>Italy</subject><subject>lactating women</subject><subject>Lactation</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Maturation</subject><subject>microbiome</subject><subject>Microbiomes</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Milk, Human - immunology</subject><subject>Molecular modelling</subject><subject>Multivariate analysis</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>protective effect</subject><subject>risk</subject><subject>Russia</subject><subject>Skin diseases</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Surveys and Questionnaires</subject><subject>Transforming growth factor</subject><subject>transforming growth factor beta</subject><subject>Transforming Growth Factor beta2 - 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chemistry</topic><topic>Colostrum - immunology</topic><topic>Common cold</topic><topic>Composition</topic><topic>diet</topic><topic>Eczema</topic><topic>Eczema - epidemiology</topic><topic>Eczema - immunology</topic><topic>Eczema - prevention & control</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Food allergies</topic><topic>genotype</topic><topic>Genotypes</topic><topic>Growth factors</topic><topic>Health</topic><topic>Hepatocyte growth factor</topic><topic>Hepatocyte Growth Factor - analysis</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - epidemiology</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Hypersensitivity, Immediate - prevention & control</topic><topic>Immunology</topic><topic>Incidence</topic><topic>Infant</topic><topic>Interleukin 1</topic><topic>Interleukin 13</topic><topic>Interleukin-13 - analysis</topic><topic>interleukin-2</topic><topic>Interleukin-2 - analysis</topic><topic>Italy</topic><topic>lactating women</topic><topic>Lactation</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Maturation</topic><topic>microbiome</topic><topic>Microbiomes</topic><topic>Milk</topic><topic>Milk, Human - 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Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munblit, Daniel</au><au>Treneva, Marina</au><au>Peroni, Diego G</au><au>Colicino, Silvia</au><au>Chow, Li Yan</au><au>Dissanayeke, Shobana</au><au>Pampura, Alexander</au><au>Boner, Attilio L</au><au>Geddes, Donna T</au><au>Boyle, Robert J</au><au>Warner, John O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-05-24</date><risdate>2017</risdate><volume>9</volume><issue>6</issue><spage>532</spage><pages>532-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules. Statistical analyses used models adjusting for the site of collection, colostrum collection time, parity and maternal atopic status. Preliminary univariate analysis showed detectable interleukin (IL) 2 and IL13 in HM to be associated with less eczema. This finding was further confirmed in multivariate analysis, with detectable HM IL13 showing protective effect OR 0.18 (95% CI 0.04-0.92). In contrast, a higher risk of eczema was associated with higher HM concentrations of transforming growth factor β (TGFβ) 2 OR 1.04 (95% CI 1.01-1.06) per ng/mL. Parental-reported food allergy was reported less often when IL13 was detectable in colostrum OR 0.10 (95% CI 0.01-0.83). HM hepatocyte growth factor (HGF) was protective for common cold incidence at 12 months OR 0.19 (95% CI 0.04-0.92) per ng/mL. Data from this study suggests that differences in the individual immune composition of HM may have an influence on early life infant health outcomes. Increased TGFβ2 levels in HM are associated with a higher incidence of reported eczema, with detectable IL13 in colostrum showing protective effects for food allergy and sensitization. HGF shows some protective effect on common cold incidence at one year of age. Future studies should be focused on maternal genotype, human milk microbiome and diet influence on human milk immune composition and both short- and long-term health outcomes in the infant.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28538696</pmid><doi>10.3390/nu9060532</doi><orcidid>https://orcid.org/0000-0001-9652-6856</orcidid><orcidid>https://orcid.org/0000-0002-4913-7580</orcidid><orcidid>https://orcid.org/0000-0002-0234-1373</orcidid><orcidid>https://orcid.org/0000-0002-0262-6280</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2017-05, Vol.9 (6), p.532 |
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| subjects | Atopy Baby foods Breast feeding Breast milk childhood Children Colostrum Colostrum - chemistry Colostrum - immunology Common cold Composition diet Eczema Eczema - epidemiology Eczema - immunology Eczema - prevention & control Female Follow-Up Studies Food allergies genotype Genotypes Growth factors Health Hepatocyte growth factor Hepatocyte Growth Factor - analysis Humans Hypersensitivity, Immediate - epidemiology Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - prevention & control Immunology Incidence Infant Interleukin 1 Interleukin 13 Interleukin-13 - analysis interleukin-2 Interleukin-2 - analysis Italy lactating women Lactation Male Mathematical models Maturation microbiome Microbiomes Milk Milk, Human - chemistry Milk, Human - immunology Molecular modelling Multivariate analysis Pregnancy Prevalence Prospective Studies protective effect risk Russia Skin diseases Statistical analysis Statistical methods Surveys and Questionnaires Transforming growth factor transforming growth factor beta Transforming Growth Factor beta2 - analysis Transforming growth factor-b United Kingdom |
| title | Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis |
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