Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin

Developing approaches to discover protein-protein interactions (PPIs) remains a fundamental challenge. A chemical biology platform is applied here to identify novel PPIs for the AAA+ superfamily oncoprotein reptin. An screen coupled with chemical optimization provided Liddean, a nucleotide-mimetic w...

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Veröffentlicht in:	Chemical science (Cambridge) 2015-05, Vol.6 (5), p.3109-3116
Hauptverfasser:	Healy, Alan R, Houston, Douglas R, Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M, Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A, Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D, Westwood, Nicholas J, Hupp, Ted R
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Combinatorial analysis Landscapes Nuclei Peptides Phage Proteins Sequencing Tumors
Online-Zugang:	Volltext
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