HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates

Objectives This study sought to test the hypothesis that hyperpolarization-activated cyclic nucleotide–gated (HCN)–based biological pacing might be improved significantly by hyperpolarizing the action potential (AP) threshold via coexpression of the skeletal muscle sodium channel 1 (SkM1). Backgroun...

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Veröffentlicht in:	Journal of the American College of Cardiology 2013-03, Vol.61 (11), p.1192-1201
Hauptverfasser:	Boink, Gerard J.J., MSc, Duan, Lian, MD, Nearing, Bruce D., PhD, Shlapakova, Iryna N., MD, Sosunov, Eugene A., PhD, Anyukhovsky, Evgeny P., PhD, Bobkov, Eugene, BSC, Kryukova, Yelena, PhD, Ozgen, Nazira, MD, PhD, Danilo, Peter, PhD, Cohen, Ira S., MD, PhD, Verrier, Richard L., PhD, Robinson, Richard B., PhD, Rosen, Michael R., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cardiovascular Dogs gene therapy Gene Transfer Techniques HCN channels Heart heart block Heart Conduction System Heart Rate - physiology Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Internal Medicine Ion Channels - genetics Medical sciences Muscle Proteins - genetics pacemakers Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) sodium channels
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