Apolipoprotein(a) inhibits hepatitis C virus entry through interaction with infectious particles

The development of different cell culture models has greatly contributed to increased understanding of the hepatitis C virus (HCV) life cycle. However, it is still challenging to grow HCV clinical isolates in cell culture. If overcome, this would open new perspectives to study HCV biology, including...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2017-06, Vol.65 (6), p.1851-1864
Hauptverfasser:	Oliveira, Catarina, Fournier, Carole, Descamps, Véronique, Morel, Virginie, Scipione, Corey A., Romagnuolo, Rocco, Koschinsky, Marlys L., Boullier, Agnès, Marcelo, Paulo, Domon, Jean‐Marc, Brochot, Etienne, Duverlie, Gilles, Francois, Catherine, Castelain, Sandrine, Helle, Francois
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Apolipoprotein B Apolipoproteins Blotting, Western Cell culture Cell Survival - drug effects Cells, Cultured Chromatography, Liquid - methods Clinical isolates Disulfide bonds Drug resistance Hepacivirus - drug effects Hepacivirus - metabolism Hepatitis Hepatitis C Hepatitis C - blood Hepatitis C - therapy Hepatocytes - drug effects Hepatocytes - metabolism Hepatology Humans Immunoprecipitation Isoforms Life cycles Life Sciences Lipid metabolism Lipoprotein(a) - pharmacology Low density lipoprotein Lysine Lysine - metabolism Polyethylene glycol Protein Binding Sensitivity and Specificity Structure-Activity Relationship Viral Hepatitis
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