Evaluation of the Pharmacokinetics and Pharmacodynamics of Prasugrel in Japanese Elderly Subjects

Background and Objective An increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and pharmacodynamic effects of prasugrel at the clinica...

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Veröffentlicht in:	Clinical drug investigation 2017-07, Vol.37 (7), p.679-685
Hauptverfasser:	Hasunuma, Tomoko, Fukase, Hiroyuki, Miyazaki, Atsuhiro, Nishikawa, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adenosine diphosphate Aged Aged, 80 and over Blood platelets Cardiovascular disease Clinical trials Drug dosages Female Heart attacks Humans Internal Medicine Japan Male Mass spectrometry Medicine Medicine & Public Health Middle Aged Original Original Research Article Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Piperazines - pharmacokinetics Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacokinetics Platelet Aggregation Inhibitors - pharmacology Platelet Function Tests Prasugrel Hydrochloride - administration & dosage Prasugrel Hydrochloride - pharmacokinetics Prasugrel Hydrochloride - pharmacology Scientific imaging
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