Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer's Disease?

Alzheimer's disease (AD) is a multifaceted disease that is hard to treat by single-modal treatment. AD starts with amyloid peptides, mitochondrial dysfunction, and oxidative stress and later is accompanied with chronic endoplasmic reticulum (ER) stress and autophagy dysfunction, resulting in mo...

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Veröffentlicht in:	International journal of molecular sciences 2017-05, Vol.18 (6), p.1168
Hauptverfasser:	Murphy, Kelsey E, Park, Joshua J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Animals Antioxidants Antioxidants - pharmacology Autophagy Brain - drug effects Brain - metabolism Cytochrome Disease Progression Endoplasmic reticulum Enzymes Free radicals Homeostasis Humans Kinases Lipids Mitochondria Neurons - drug effects Neurons - metabolism NF-E2-Related Factor 2 - metabolism Nitrogen dioxide Organelles Oxidative stress Oxidative Stress - drug effects Pathogenesis Peptides Protein synthesis Proteins Review Signal Transduction Tumor necrosis factor-TNF
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