Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression o...
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| Veröffentlicht in: | Oncogene 2017-06, Vol.36 (24), p.3359-3374 |
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| creator | Wong, C C Qian, Y Yu, J |
| description | Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. In this review, we summarized the recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis; and highlighted the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer. |
| doi_str_mv | 10.1038/onc.2016.485 |
| format | Article |
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Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. In this review, we summarized the recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis; and highlighted the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2016.485</identifier><identifier>PMID: 28092669</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/23 ; 631/67/1059/153 ; 631/67/2327 ; 631/67/68 ; Analysis ; Apoptosis ; Cancer ; Carcinogenesis ; Carcinogenesis - genetics ; Carcinogenesis - metabolism ; Cell Biology ; Cell Proliferation ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; Enzymes ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Gene Expression Regulation, Neoplastic ; Histones - metabolism ; Human Genetics ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolism ; Metabolites ; Metabolomics ; Metastases ; Neoplasm Metastasis ; Oncology ; Pluripotency ; Review ; Therapeutics ; Tumorigenesis</subject><ispartof>Oncogene, 2017-06, Vol.36 (24), p.3359-3374</ispartof><rights>The Author(s) 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 15, 2017</rights><rights>Copyright © 2017 The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-9ee670ae19db32ee966223c4c7ca6dfbc1c17392b1a22ffc8ae4c45802e7d4733</citedby><cites>FETCH-LOGICAL-c583t-9ee670ae19db32ee966223c4c7ca6dfbc1c17392b1a22ffc8ae4c45802e7d4733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/onc.2016.485$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/onc.2016.485$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28092669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, C C</creatorcontrib><creatorcontrib>Qian, Y</creatorcontrib><creatorcontrib>Yu, J</creatorcontrib><title>Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. In this review, we summarized the recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis; and highlighted the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer.</description><subject>45/23</subject><subject>631/67/1059/153</subject><subject>631/67/2327</subject><subject>631/67/68</subject><subject>Analysis</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - metabolism</subject><subject>Cell Biology</subject><subject>Cell Proliferation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Enzymes</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Histones - metabolism</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Metastases</subject><subject>Neoplasm Metastasis</subject><subject>Oncology</subject><subject>Pluripotency</subject><subject>Review</subject><subject>Therapeutics</subject><subject>Tumorigenesis</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1r3DAQxUVpaLZpbz0XQy891Bt92JLVQyGEfgQCuaRnIcvjXQVbciW7Jf99x2y6JCXoIND7zRs9aQh5x-iWUdGcx-C2nDK5rZr6BdmwSsmyrnX1kmyormmpueCn5HXOd5RSpSl_RU55QzWXUm9IexVmSNNg74sW5j8AoYDJ7yDA7F0ubOiKEWbbxsHnsfChwHZxlbPPn1FyextQOZDzHpKdYMHSwk5TitbtIb8hJ70dMrx92M_Iz29fby9_lNc3368uL65LVzdiLjWAVNQC010rOICWknPhKqeclV3fOuaYEpq3zHLe966xULmqbigH1VVKiDPy5eA7Le0InYMwJzuYKfnRpnsTrTdPleD3Zhd_mxpfjimFBh8fDFL8tUCezeizg2GwAeKSDWskq4WuxIp--A-9i0sKGM8wTfHqjcJQR2pnBzA-9BH7utXUXFQaPwkT1khtn6FwdTB6FwP0Hs-fFHw6FLgUc07QHzMyataZMPhJZp0Jg8kQf__4XY7wvyFAoDwAGaWwg_QozHOGfwEEm8KN</recordid><startdate>20170615</startdate><enddate>20170615</enddate><creator>Wong, C C</creator><creator>Qian, Y</creator><creator>Yu, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170615</creationdate><title>Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches</title><author>Wong, C C ; Qian, Y ; Yu, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-9ee670ae19db32ee966223c4c7ca6dfbc1c17392b1a22ffc8ae4c45802e7d4733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>45/23</topic><topic>631/67/1059/153</topic><topic>631/67/2327</topic><topic>631/67/68</topic><topic>Analysis</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - metabolism</topic><topic>Cell Biology</topic><topic>Cell Proliferation</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>Enzymes</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Histones - metabolism</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Metastases</topic><topic>Neoplasm Metastasis</topic><topic>Oncology</topic><topic>Pluripotency</topic><topic>Review</topic><topic>Therapeutics</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, C C</creatorcontrib><creatorcontrib>Qian, Y</creatorcontrib><creatorcontrib>Yu, J</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, C C</au><au>Qian, Y</au><au>Yu, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2017-06-15</date><risdate>2017</risdate><volume>36</volume><issue>24</issue><spage>3359</spage><epage>3374</epage><pages>3359-3374</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. 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| subjects | 45/23 631/67/1059/153 631/67/2327 631/67/68 Analysis Apoptosis Cancer Carcinogenesis Carcinogenesis - genetics Carcinogenesis - metabolism Cell Biology Cell Proliferation Deoxyribonucleic acid DNA DNA Methylation Enzymes Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene Expression Regulation, Neoplastic Histones - metabolism Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metabolism Metabolites Metabolomics Metastases Neoplasm Metastasis Oncology Pluripotency Review Therapeutics Tumorigenesis |
| title | Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches |
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