STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis

BACKGROUND Macrophages are highly heterogeneous and plastic cells that are involved in all stages of atherogenesis. They can undergo polarization by shifting between M1 and M2 functional phenotypes. However, the role of macrophage polarization and the molecular mechanism in modulating atheroscleroti...

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Veröffentlicht in:	Medical science monitor. Basic research 2017-06, Vol.23, p.240-249
Hauptverfasser:	Gong, Min, Zhuo, Xiaozhen, Ma, Aiqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Studies Animals Apoptosis - physiology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - therapy Cell Differentiation - physiology Cell Polarity - physiology Disease Models, Animal Lipoproteins, LDL - metabolism Macrophage Activation - physiology Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Phenotype Plaque, Atherosclerotic - metabolism RAW 264.7 Cells STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism Up-Regulation Wnt Signaling Pathway
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