Progressive Loss of Function in a Limb Enhancer during Snake Evolution

The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence changes within an otherwise highly conserved long...

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Veröffentlicht in:	Cell 2016-10, Vol.167 (3), p.633-642.e11
Hauptverfasser:	Kvon, Evgeny Z., Kamneva, Olga K., Melo, Uirá S., Barozzi, Iros, Osterwalder, Marco, Mannion, Brandon J., Tissières, Virginie, Pickle, Catherine S., Plajzer-Frick, Ingrid, Lee, Elizabeth A., Kato, Momoe, Garvin, Tyler H., Akiyama, Jennifer A., Afzal, Veena, Lopez-Rios, Javier, Rubin, Edward M., Dickel, Diane E., Pennacchio, Len A., Visel, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence BASIC BIOLOGICAL SCIENCES binding sites Biological Evolution cis-regulatory element CRISPR/Cas9 enhancer Enhancer Elements, Genetic evo-devo evolution Evolution, Molecular Extremities - growth & development fish Gene Knock-In Techniques genome editing Hedgehog Proteins - genetics humans limb development Mice Mice, Transgenic morphological evolution Mutation Phylogeny regulatory sequences snakes Snakes - classification Snakes - genetics Sonic hedgehog (Shh) transcription factors transgenic animals ZRS
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