Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative

Abstract Objective Previous studies involving large administrative data sets have revealed regional variation in the demographics of patients selected for carotid endarterectomy (CEA) and carotid artery stenting (CAS) but lacked clinical granularity. This study aimed to evaluate regional variation i...

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Veröffentlicht in:Journal of vascular surgery 2017-07, Vol.66 (1), p.112-121
Hauptverfasser: Shean, Katie E., MD, McCallum, John C., MD, Soden, Peter A., MD, Deery, Sarah E., MD, Schneider, Joseph R., MD, PhD, Nolan, Brian W., MD, Rockman, Caron B., MD, Schermerhorn, Marc L., MD, FACS
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container_end_page 121
container_issue 1
container_start_page 112
container_title Journal of vascular surgery
container_volume 66
creator Shean, Katie E., MD
McCallum, John C., MD
Soden, Peter A., MD
Deery, Sarah E., MD
Schneider, Joseph R., MD, PhD
Nolan, Brian W., MD
Rockman, Caron B., MD
Schermerhorn, Marc L., MD, FACS
description Abstract Objective Previous studies involving large administrative data sets have revealed regional variation in the demographics of patients selected for carotid endarterectomy (CEA) and carotid artery stenting (CAS) but lacked clinical granularity. This study aimed to evaluate regional variation in patient selection and operative technique for carotid artery revascularization using a detailed clinical registry. Methods All patients who underwent CEA or CAS from 2009 to 2015 were identified in the Vascular Quality Initiative (VQI). Deidentified regional groups were used to evaluate variation in patient selection, operative technique, and perioperative management. χ2 analysis was used to identify significant variation across regions. Results A total of 57,555 carotid artery revascularization procedures were identified. Of these, 49,179 patients underwent CEA (asymptomatic: median, 56%; range, 46%-69%; P  < .01) and 8376 patients underwent CAS (asymptomatic: median, 36%; range, 29%-51%; P  < .01). There was significant regional variation in the proportion of asymptomatic patients being treated for carotid stenosis 
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This study aimed to evaluate regional variation in patient selection and operative technique for carotid artery revascularization using a detailed clinical registry. Methods All patients who underwent CEA or CAS from 2009 to 2015 were identified in the Vascular Quality Initiative (VQI). Deidentified regional groups were used to evaluate variation in patient selection, operative technique, and perioperative management. χ2 analysis was used to identify significant variation across regions. Results A total of 57,555 carotid artery revascularization procedures were identified. Of these, 49,179 patients underwent CEA (asymptomatic: median, 56%; range, 46%-69%; P  < .01) and 8376 patients underwent CAS (asymptomatic: median, 36%; range, 29%-51%; P  < .01). There was significant regional variation in the proportion of asymptomatic patients being treated for carotid stenosis <70% in CEA (3%-9%; P  < .01) vs CAS (3%-22%; P  < .01). There was also significant variation in the rates of intervention for asymptomatic patients older than 80 years (CEA, 12%-27% [ P  < .01]; CAS, 8%-26% [ P  < .01]). Preoperative computed tomography angiography or magnetic resonance angiography in the CAS cohort also varied widely (31%-83%; P  < .01), as did preoperative medical management with combined aspirin and statin (CEA, 53%-77% [ P  < .01]; CAS, 62%-80% [ P  < .01]). In the CEA group, the use of shunt (36%-83%; P  < .01), protamine (32%-89%; P  < .01), and patch (87%-99%; P  < .01) varied widely. Similarly, there was regional variation in frequency of CAS done without a protection device (1%-8%; P  < .01). Conclusions Despite clinical benchmarks aimed at guiding management of carotid disease, wide variation in clinical practice exists, including the proportion of asymptomatic patients being treated by CAS and preoperative medical management. Additional intraoperative variables, including the use of a patch and protamine during CEA and use of a protection device during CAS, displayed similar variation in spite of clear guidelines. Quality improvement projects could be directed toward improved adherence to benchmarks in these areas.]]></description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2017.01.023</identifier><identifier>PMID: 28359719</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Angioplasty - adverse effects ; Angioplasty - instrumentation ; Angioplasty - trends ; Benchmarking - trends ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - surgery ; Carotid Stenosis - therapy ; Chi-Square Distribution ; Computed Tomography Angiography - trends ; Endarterectomy, Carotid - adverse effects ; Endarterectomy, Carotid - trends ; Female ; Guideline Adherence - trends ; Healthcare Disparities - trends ; Humans ; Magnetic Resonance Angiography - trends ; Male ; Patient Selection ; Practice Guidelines as Topic ; Practice Patterns, Physicians' - trends ; Predictive Value of Tests ; Process Assessment (Health Care) - trends ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgery ; Time Factors ; Treatment Outcome ; United States</subject><ispartof>Journal of vascular surgery, 2017-07, Vol.66 (1), p.112-121</ispartof><rights>Society for Vascular Surgery</rights><rights>2017 Society for Vascular Surgery</rights><rights>Copyright © 2017 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-3c1971466d770aeb8068c724d36202cc4a21647252ec5b949bc83bfebfa70113</citedby><cites>FETCH-LOGICAL-c506t-3c1971466d770aeb8068c724d36202cc4a21647252ec5b949bc83bfebfa70113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S074152141730191X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28359719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shean, Katie E., MD</creatorcontrib><creatorcontrib>McCallum, John C., MD</creatorcontrib><creatorcontrib>Soden, Peter A., MD</creatorcontrib><creatorcontrib>Deery, Sarah E., MD</creatorcontrib><creatorcontrib>Schneider, Joseph R., MD, PhD</creatorcontrib><creatorcontrib>Nolan, Brian W., MD</creatorcontrib><creatorcontrib>Rockman, Caron B., MD</creatorcontrib><creatorcontrib>Schermerhorn, Marc L., MD, FACS</creatorcontrib><creatorcontrib>Society for Vascular Surgery Vascular Quality Initiative</creatorcontrib><title>Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description><![CDATA[Abstract Objective Previous studies involving large administrative data sets have revealed regional variation in the demographics of patients selected for carotid endarterectomy (CEA) and carotid artery stenting (CAS) but lacked clinical granularity. This study aimed to evaluate regional variation in patient selection and operative technique for carotid artery revascularization using a detailed clinical registry. Methods All patients who underwent CEA or CAS from 2009 to 2015 were identified in the Vascular Quality Initiative (VQI). Deidentified regional groups were used to evaluate variation in patient selection, operative technique, and perioperative management. χ2 analysis was used to identify significant variation across regions. Results A total of 57,555 carotid artery revascularization procedures were identified. Of these, 49,179 patients underwent CEA (asymptomatic: median, 56%; range, 46%-69%; P  < .01) and 8376 patients underwent CAS (asymptomatic: median, 36%; range, 29%-51%; P  < .01). There was significant regional variation in the proportion of asymptomatic patients being treated for carotid stenosis <70% in CEA (3%-9%; P  < .01) vs CAS (3%-22%; P  < .01). There was also significant variation in the rates of intervention for asymptomatic patients older than 80 years (CEA, 12%-27% [ P  < .01]; CAS, 8%-26% [ P  < .01]). Preoperative computed tomography angiography or magnetic resonance angiography in the CAS cohort also varied widely (31%-83%; P  < .01), as did preoperative medical management with combined aspirin and statin (CEA, 53%-77% [ P  < .01]; CAS, 62%-80% [ P  < .01]). In the CEA group, the use of shunt (36%-83%; P  < .01), protamine (32%-89%; P  < .01), and patch (87%-99%; P  < .01) varied widely. Similarly, there was regional variation in frequency of CAS done without a protection device (1%-8%; P  < .01). Conclusions Despite clinical benchmarks aimed at guiding management of carotid disease, wide variation in clinical practice exists, including the proportion of asymptomatic patients being treated by CAS and preoperative medical management. Additional intraoperative variables, including the use of a patch and protamine during CEA and use of a protection device during CAS, displayed similar variation in spite of clear guidelines. Quality improvement projects could be directed toward improved adherence to benchmarks in these areas.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty - adverse effects</subject><subject>Angioplasty - instrumentation</subject><subject>Angioplasty - trends</subject><subject>Benchmarking - trends</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - surgery</subject><subject>Carotid Stenosis - therapy</subject><subject>Chi-Square Distribution</subject><subject>Computed Tomography Angiography - trends</subject><subject>Endarterectomy, Carotid - adverse effects</subject><subject>Endarterectomy, Carotid - trends</subject><subject>Female</subject><subject>Guideline Adherence - trends</subject><subject>Healthcare Disparities - trends</subject><subject>Humans</subject><subject>Magnetic Resonance Angiography - trends</subject><subject>Male</subject><subject>Patient Selection</subject><subject>Practice Guidelines as Topic</subject><subject>Practice Patterns, Physicians' - trends</subject><subject>Predictive Value of Tests</subject><subject>Process Assessment (Health Care) - trends</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>United States</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksFu1DAQhiMEotvCA3BBPnJJ8NhJ7AipEqqAVqqEgApxsxxn0nrxxovtRNq3x2FLBRw4eWTP_8-MvymKF0AroNC-3lbbJVaMgqgoVJTxR8UGaCfKVtLucbGhooayYVCfFKcxbikFaKR4WpwwyZtOQLcp4me8tX7Sjiw6WJ1yTOxE9jnCKZGIDs2vSz0NJAXUabfejz4Qo4NPdiA6JAwHMtiIOuKqTndIvupoZqcD-TRrZ9OBXE02rQUWfFY8GbWL-Pz-PCtu3r-7ubgsrz9-uLp4e12ahrap5AZyj3XbDkJQjb2krTSC1QNvGWXG1JpBWwvWMDRN39VdbyTvR-xHLfKk_Kw4P9ru536Hg8l9B-3UPtidDgfltVV_v0z2Tt36RTW15Fy22eDVvUHwP2aMSe1sNOicntDPUYGUHCQFvtaCY6oJPsaA40MZoGplpbYqs1IrK0VBZVZZ8_LP_h4Uv-HkhDfHBMyftFgMKppMxeBgQ6aiBm__a3_-j9o4O1mj3Xc8YNz6OWTseQoVmaLqy7os666A4BQ6-MZ_AuZMvJM</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Shean, Katie E., MD</creator><creator>McCallum, John C., MD</creator><creator>Soden, Peter A., MD</creator><creator>Deery, Sarah E., MD</creator><creator>Schneider, Joseph R., MD, PhD</creator><creator>Nolan, Brian W., MD</creator><creator>Rockman, Caron B., MD</creator><creator>Schermerhorn, Marc L., MD, FACS</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170701</creationdate><title>Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative</title><author>Shean, Katie E., MD ; McCallum, John C., MD ; Soden, Peter A., MD ; Deery, Sarah E., MD ; Schneider, Joseph R., MD, PhD ; Nolan, Brian W., MD ; Rockman, Caron B., MD ; Schermerhorn, Marc L., MD, FACS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-3c1971466d770aeb8068c724d36202cc4a21647252ec5b949bc83bfebfa70113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty - adverse effects</topic><topic>Angioplasty - instrumentation</topic><topic>Angioplasty - trends</topic><topic>Benchmarking - trends</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - surgery</topic><topic>Carotid Stenosis - therapy</topic><topic>Chi-Square Distribution</topic><topic>Computed Tomography Angiography - trends</topic><topic>Endarterectomy, Carotid - adverse effects</topic><topic>Endarterectomy, Carotid - trends</topic><topic>Female</topic><topic>Guideline Adherence - trends</topic><topic>Healthcare Disparities - trends</topic><topic>Humans</topic><topic>Magnetic Resonance Angiography - trends</topic><topic>Male</topic><topic>Patient Selection</topic><topic>Practice Guidelines as Topic</topic><topic>Practice Patterns, Physicians' - trends</topic><topic>Predictive Value of Tests</topic><topic>Process Assessment (Health Care) - trends</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shean, Katie E., MD</creatorcontrib><creatorcontrib>McCallum, John C., MD</creatorcontrib><creatorcontrib>Soden, Peter A., MD</creatorcontrib><creatorcontrib>Deery, Sarah E., MD</creatorcontrib><creatorcontrib>Schneider, Joseph R., MD, PhD</creatorcontrib><creatorcontrib>Nolan, Brian W., MD</creatorcontrib><creatorcontrib>Rockman, Caron B., MD</creatorcontrib><creatorcontrib>Schermerhorn, Marc L., MD, FACS</creatorcontrib><creatorcontrib>Society for Vascular Surgery Vascular Quality Initiative</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shean, Katie E., MD</au><au>McCallum, John C., MD</au><au>Soden, Peter A., MD</au><au>Deery, Sarah E., MD</au><au>Schneider, Joseph R., MD, PhD</au><au>Nolan, Brian W., MD</au><au>Rockman, Caron B., MD</au><au>Schermerhorn, Marc L., MD, FACS</au><aucorp>Society for Vascular Surgery Vascular Quality Initiative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>66</volume><issue>1</issue><spage>112</spage><epage>121</epage><pages>112-121</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><abstract><![CDATA[Abstract Objective Previous studies involving large administrative data sets have revealed regional variation in the demographics of patients selected for carotid endarterectomy (CEA) and carotid artery stenting (CAS) but lacked clinical granularity. This study aimed to evaluate regional variation in patient selection and operative technique for carotid artery revascularization using a detailed clinical registry. Methods All patients who underwent CEA or CAS from 2009 to 2015 were identified in the Vascular Quality Initiative (VQI). Deidentified regional groups were used to evaluate variation in patient selection, operative technique, and perioperative management. χ2 analysis was used to identify significant variation across regions. Results A total of 57,555 carotid artery revascularization procedures were identified. Of these, 49,179 patients underwent CEA (asymptomatic: median, 56%; range, 46%-69%; P  < .01) and 8376 patients underwent CAS (asymptomatic: median, 36%; range, 29%-51%; P  < .01). There was significant regional variation in the proportion of asymptomatic patients being treated for carotid stenosis <70% in CEA (3%-9%; P  < .01) vs CAS (3%-22%; P  < .01). There was also significant variation in the rates of intervention for asymptomatic patients older than 80 years (CEA, 12%-27% [ P  < .01]; CAS, 8%-26% [ P  < .01]). Preoperative computed tomography angiography or magnetic resonance angiography in the CAS cohort also varied widely (31%-83%; P  < .01), as did preoperative medical management with combined aspirin and statin (CEA, 53%-77% [ P  < .01]; CAS, 62%-80% [ P  < .01]). In the CEA group, the use of shunt (36%-83%; P  < .01), protamine (32%-89%; P  < .01), and patch (87%-99%; P  < .01) varied widely. Similarly, there was regional variation in frequency of CAS done without a protection device (1%-8%; P  < .01). Conclusions Despite clinical benchmarks aimed at guiding management of carotid disease, wide variation in clinical practice exists, including the proportion of asymptomatic patients being treated by CAS and preoperative medical management. Additional intraoperative variables, including the use of a patch and protamine during CEA and use of a protection device during CAS, displayed similar variation in spite of clear guidelines. Quality improvement projects could be directed toward improved adherence to benchmarks in these areas.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28359719</pmid><doi>10.1016/j.jvs.2017.01.023</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Aged, 80 and over
Angioplasty - adverse effects
Angioplasty - instrumentation
Angioplasty - trends
Benchmarking - trends
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - surgery
Carotid Stenosis - therapy
Chi-Square Distribution
Computed Tomography Angiography - trends
Endarterectomy, Carotid - adverse effects
Endarterectomy, Carotid - trends
Female
Guideline Adherence - trends
Healthcare Disparities - trends
Humans
Magnetic Resonance Angiography - trends
Male
Patient Selection
Practice Guidelines as Topic
Practice Patterns, Physicians' - trends
Predictive Value of Tests
Process Assessment (Health Care) - trends
Registries
Retrospective Studies
Risk Assessment
Risk Factors
Surgery
Time Factors
Treatment Outcome
United States
title Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative
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