pHisphorylation: the emergence of histidine phosphorylation as a reversible regulatory modification

Highlights • Histidine phosphorylation (pHis) is reversible by specific kinases and phosphatases. • pHis is heat and acid labile, but stable under alkaline conditions. • Stable pHis analogs have enabled development of pHis-specific antibodies. • pHis antibodies and refined methods have identified ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in cell biology 2017-04, Vol.45, p.8-16
Hauptverfasser:	Fuhs, Stephen Rush, Hunter, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Histidine - analogs & derivatives Histidine - metabolism Humans Internal Medicine Mammals - metabolism Mass Spectrometry Metabolic Networks and Pathways Phosphorylation Prokaryotic Cells - metabolism Protein Processing, Post-Translational Proteins - chemistry Proteins - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Histidine phosphorylation (pHis) is reversible by specific kinases and phosphatases. • pHis is heat and acid labile, but stable under alkaline conditions. • Stable pHis analogs have enabled development of pHis-specific antibodies. • pHis antibodies and refined methods have identified new functions and substrates. • Enrichment of pHis phosphopeptides for proteomics is the next critical step.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2016.12.010