cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress

To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was used intragastrically to inhibit the activity of cyclooxygenase 2. Moreover, cyclooxygenase 2 over-expressing or RNA interfere lenti...

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Veröffentlicht in:	Oncotarget 2017-05, Vol.8 (22), p.35558-35572
Hauptverfasser:	Luo, Ying, Kuang, Shengnan, Li, Huan, Ran, Dongzhi, Yang, Junqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain-Derived Neurotrophic Factor - metabolism Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cytokines - metabolism Disease Models, Animal Gene Expression Regulation - drug effects Hippocampus - metabolism Inflammation Mediators - metabolism Learning - drug effects Memory - drug effects Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - metabolism Memory Disorders - physiopathology Rats Research Paper: Neuroscience Signal Transduction Stress, Psychological Synapses - drug effects Synapses - metabolism Thiazines - pharmacology Thiazoles - pharmacology
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