Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes

The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are...

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Veröffentlicht in:The Journal of biological chemistry 2017-06, Vol.292 (25), p.10549-10563
Hauptverfasser: Tabaja, Nassif, Yuan, Zhenyu, Oswald, Franz, Kovall, Rhett A.
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Sprache:eng
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