Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births
Abstract Objectives We sought to assess the effect of congenital heart disease requiring infant surgery with cardiopulmonary bypass on neurodevelopmental outcomes and growth at 4 years of age, while matching for gestational age, socioeconomic status, maternal gestational conditions, home environment...
Gespeichert in:
| Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 2017-07, Vol.154 (1), p.273-281.e2 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 281.e2 |
|---|---|
| container_issue | 1 |
| container_start_page | 273 |
| container_title | The Journal of thoracic and cardiovascular surgery |
| container_volume | 154 |
| creator | Schultz, Amy H., MD, MSCE Ittenbach, Richard F., PhD Gerdes, Marsha, PhD Jarvik, Gail P., MD, PhD Wernovsky, Gil, MD Bernbaum, Judy, MD Solot, Cynthia, CCC, MA Clancy, Robert R., MD Nicolson, Susan C., MD Spray, Thomas L., MD McDonald-McGinn, Donna, MS, CGC Zackai, Elaine, MD Gaynor, J. William, MD |
| description | Abstract Objectives We sought to assess the effect of congenital heart disease requiring infant surgery with cardiopulmonary bypass on neurodevelopmental outcomes and growth at 4 years of age, while matching for gestational age, socioeconomic status, maternal gestational conditions, home environment, and parental intelligence by studying multiple-gestation births. Methods We performed within-family comparison of 14 multiple-gestation births in which 1 child had congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age. Between 4 and 5 years of age, a comprehensive neurodevelopmental assessment was performed. Paired comparisons were conducted between siblings with and without heart defects using a series of nonparametric tests. Results On average, the children qualified as late preterm (mean gestational age 35.4 ± 2.6 weeks). At an average age of 4.8 ± 0.1 years, children with congenital heart disease weighed less than their siblings (median weight for age z score −0.4 vs 0.1, P = .02) and had worse performance for cognition (median full-scale IQ 99 vs 109, P = .02) and fine motor skills (median Wide Range Assessment of Visual Motor Ability, Fine Motor score 94.5 vs 107.5, P |
| doi_str_mv | 10.1016/j.jtcvs.2017.02.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5481170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022522317302623</els_id><sourcerecordid>1879663036</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-e033d526842cee0fc1a70c76d2425b3cd0a4ff19398612dee91cc315015f2fd93</originalsourceid><addsrcrecordid>eNqFkk2LFDEQhoMo7uzqLxCkj156rCT9eXBBll1XWPCggidDJqnMpM0kY5IemX9vxlkX9SIUBCrvW1XJU4S8oLCkQLvX03LKap-WDGi_BFaCPSILCmNfd0P75TFZQEnVLWP8jJynNAFAD3R8Ss7YwBm0lC3I12tjUOUqmEoFv0Zvs3TVBmXMlbYJZcIq-KqpDyVVeZxj0LhHF3Zb9Ln6YfPG-mo7u2x3Dus1piyzLY6VjXmTnpEnRrqEz-_PC_L55vrT1W199-Hd-6u3d7VqaZNrBM51y7qhYQoRjKKyB9V3mjWsXXGlQTbG0JGPQ0eZRhypUpy2QFvDjB75Bbk81d3Nqy1qVWaL0oldtFsZDyJIK_6-8XYj1mEv2magtIdS4NV9gRi-z-UVYmuTQuekxzAnQYd-7DoOvCtSfpKqGFKKaB7aUBBHMmISv8iIIxkBrAQrrpd_Tvjg-Y2iCN6cBFj-aW8xiqQseoXaxkJI6GD_0-DyH79y1lsl3Tc8YJrCHH1BIKhIxSA-HpfjuBu058A6xvlP1hy31Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1879663036</pqid></control><display><type>article</type><title>Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Schultz, Amy H., MD, MSCE ; Ittenbach, Richard F., PhD ; Gerdes, Marsha, PhD ; Jarvik, Gail P., MD, PhD ; Wernovsky, Gil, MD ; Bernbaum, Judy, MD ; Solot, Cynthia, CCC, MA ; Clancy, Robert R., MD ; Nicolson, Susan C., MD ; Spray, Thomas L., MD ; McDonald-McGinn, Donna, MS, CGC ; Zackai, Elaine, MD ; Gaynor, J. William, MD</creator><creatorcontrib>Schultz, Amy H., MD, MSCE ; Ittenbach, Richard F., PhD ; Gerdes, Marsha, PhD ; Jarvik, Gail P., MD, PhD ; Wernovsky, Gil, MD ; Bernbaum, Judy, MD ; Solot, Cynthia, CCC, MA ; Clancy, Robert R., MD ; Nicolson, Susan C., MD ; Spray, Thomas L., MD ; McDonald-McGinn, Donna, MS, CGC ; Zackai, Elaine, MD ; Gaynor, J. William, MD</creatorcontrib><description>Abstract Objectives We sought to assess the effect of congenital heart disease requiring infant surgery with cardiopulmonary bypass on neurodevelopmental outcomes and growth at 4 years of age, while matching for gestational age, socioeconomic status, maternal gestational conditions, home environment, and parental intelligence by studying multiple-gestation births. Methods We performed within-family comparison of 14 multiple-gestation births in which 1 child had congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age. Between 4 and 5 years of age, a comprehensive neurodevelopmental assessment was performed. Paired comparisons were conducted between siblings with and without heart defects using a series of nonparametric tests. Results On average, the children qualified as late preterm (mean gestational age 35.4 ± 2.6 weeks). At an average age of 4.8 ± 0.1 years, children with congenital heart disease weighed less than their siblings (median weight for age z score −0.4 vs 0.1, P = .02) and had worse performance for cognition (median full-scale IQ 99 vs 109, P = .02) and fine motor skills (median Wide Range Assessment of Visual Motor Ability, Fine Motor score 94.5 vs 107.5, P < .01). Conclusions After controlling for socioeconomic status, home environment, parental intelligence, and gestational factors by using multiple-gestation births, congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age is associated with lower weight, cognitive abilities and fine motor skills at 4 years of age.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/j.jtcvs.2017.02.022</identifier><identifier>PMID: 28320512</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>cardiac surgery ; Cardiopulmonary Bypass ; Cardiothoracic Surgery ; Child Development ; Child, Preschool ; complications ; congenital ; etiology ; Female ; Follow-Up Studies ; heart defects ; Heart Defects, Congenital - complications ; Heart Defects, Congenital - surgery ; Humans ; Infant ; Male ; Multiple Birth Offspring ; neurodevelopmental disorders ; Neurodevelopmental Disorders - etiology ; Time Factors ; triplets ; twins</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 2017-07, Vol.154 (1), p.273-281.e2</ispartof><rights>The American Association for Thoracic Surgery</rights><rights>2017 The American Association for Thoracic Surgery</rights><rights>Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-e033d526842cee0fc1a70c76d2425b3cd0a4ff19398612dee91cc315015f2fd93</citedby><cites>FETCH-LOGICAL-c514t-e033d526842cee0fc1a70c76d2425b3cd0a4ff19398612dee91cc315015f2fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022522317302623$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28320512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schultz, Amy H., MD, MSCE</creatorcontrib><creatorcontrib>Ittenbach, Richard F., PhD</creatorcontrib><creatorcontrib>Gerdes, Marsha, PhD</creatorcontrib><creatorcontrib>Jarvik, Gail P., MD, PhD</creatorcontrib><creatorcontrib>Wernovsky, Gil, MD</creatorcontrib><creatorcontrib>Bernbaum, Judy, MD</creatorcontrib><creatorcontrib>Solot, Cynthia, CCC, MA</creatorcontrib><creatorcontrib>Clancy, Robert R., MD</creatorcontrib><creatorcontrib>Nicolson, Susan C., MD</creatorcontrib><creatorcontrib>Spray, Thomas L., MD</creatorcontrib><creatorcontrib>McDonald-McGinn, Donna, MS, CGC</creatorcontrib><creatorcontrib>Zackai, Elaine, MD</creatorcontrib><creatorcontrib>Gaynor, J. William, MD</creatorcontrib><title>Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>Abstract Objectives We sought to assess the effect of congenital heart disease requiring infant surgery with cardiopulmonary bypass on neurodevelopmental outcomes and growth at 4 years of age, while matching for gestational age, socioeconomic status, maternal gestational conditions, home environment, and parental intelligence by studying multiple-gestation births. Methods We performed within-family comparison of 14 multiple-gestation births in which 1 child had congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age. Between 4 and 5 years of age, a comprehensive neurodevelopmental assessment was performed. Paired comparisons were conducted between siblings with and without heart defects using a series of nonparametric tests. Results On average, the children qualified as late preterm (mean gestational age 35.4 ± 2.6 weeks). At an average age of 4.8 ± 0.1 years, children with congenital heart disease weighed less than their siblings (median weight for age z score −0.4 vs 0.1, P = .02) and had worse performance for cognition (median full-scale IQ 99 vs 109, P = .02) and fine motor skills (median Wide Range Assessment of Visual Motor Ability, Fine Motor score 94.5 vs 107.5, P < .01). Conclusions After controlling for socioeconomic status, home environment, parental intelligence, and gestational factors by using multiple-gestation births, congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age is associated with lower weight, cognitive abilities and fine motor skills at 4 years of age.</description><subject>cardiac surgery</subject><subject>Cardiopulmonary Bypass</subject><subject>Cardiothoracic Surgery</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>complications</subject><subject>congenital</subject><subject>etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>heart defects</subject><subject>Heart Defects, Congenital - complications</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Multiple Birth Offspring</subject><subject>neurodevelopmental disorders</subject><subject>Neurodevelopmental Disorders - etiology</subject><subject>Time Factors</subject><subject>triplets</subject><subject>twins</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7uzqLxCkj156rCT9eXBBll1XWPCggidDJqnMpM0kY5IemX9vxlkX9SIUBCrvW1XJU4S8oLCkQLvX03LKap-WDGi_BFaCPSILCmNfd0P75TFZQEnVLWP8jJynNAFAD3R8Ss7YwBm0lC3I12tjUOUqmEoFv0Zvs3TVBmXMlbYJZcIq-KqpDyVVeZxj0LhHF3Zb9Ln6YfPG-mo7u2x3Dus1piyzLY6VjXmTnpEnRrqEz-_PC_L55vrT1W199-Hd-6u3d7VqaZNrBM51y7qhYQoRjKKyB9V3mjWsXXGlQTbG0JGPQ0eZRhypUpy2QFvDjB75Bbk81d3Nqy1qVWaL0oldtFsZDyJIK_6-8XYj1mEv2magtIdS4NV9gRi-z-UVYmuTQuekxzAnQYd-7DoOvCtSfpKqGFKKaB7aUBBHMmISv8iIIxkBrAQrrpd_Tvjg-Y2iCN6cBFj-aW8xiqQseoXaxkJI6GD_0-DyH79y1lsl3Tc8YJrCHH1BIKhIxSA-HpfjuBu058A6xvlP1hy31Q</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Schultz, Amy H., MD, MSCE</creator><creator>Ittenbach, Richard F., PhD</creator><creator>Gerdes, Marsha, PhD</creator><creator>Jarvik, Gail P., MD, PhD</creator><creator>Wernovsky, Gil, MD</creator><creator>Bernbaum, Judy, MD</creator><creator>Solot, Cynthia, CCC, MA</creator><creator>Clancy, Robert R., MD</creator><creator>Nicolson, Susan C., MD</creator><creator>Spray, Thomas L., MD</creator><creator>McDonald-McGinn, Donna, MS, CGC</creator><creator>Zackai, Elaine, MD</creator><creator>Gaynor, J. William, MD</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170701</creationdate><title>Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births</title><author>Schultz, Amy H., MD, MSCE ; Ittenbach, Richard F., PhD ; Gerdes, Marsha, PhD ; Jarvik, Gail P., MD, PhD ; Wernovsky, Gil, MD ; Bernbaum, Judy, MD ; Solot, Cynthia, CCC, MA ; Clancy, Robert R., MD ; Nicolson, Susan C., MD ; Spray, Thomas L., MD ; McDonald-McGinn, Donna, MS, CGC ; Zackai, Elaine, MD ; Gaynor, J. William, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-e033d526842cee0fc1a70c76d2425b3cd0a4ff19398612dee91cc315015f2fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>cardiac surgery</topic><topic>Cardiopulmonary Bypass</topic><topic>Cardiothoracic Surgery</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>complications</topic><topic>congenital</topic><topic>etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>heart defects</topic><topic>Heart Defects, Congenital - complications</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Multiple Birth Offspring</topic><topic>neurodevelopmental disorders</topic><topic>Neurodevelopmental Disorders - etiology</topic><topic>Time Factors</topic><topic>triplets</topic><topic>twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schultz, Amy H., MD, MSCE</creatorcontrib><creatorcontrib>Ittenbach, Richard F., PhD</creatorcontrib><creatorcontrib>Gerdes, Marsha, PhD</creatorcontrib><creatorcontrib>Jarvik, Gail P., MD, PhD</creatorcontrib><creatorcontrib>Wernovsky, Gil, MD</creatorcontrib><creatorcontrib>Bernbaum, Judy, MD</creatorcontrib><creatorcontrib>Solot, Cynthia, CCC, MA</creatorcontrib><creatorcontrib>Clancy, Robert R., MD</creatorcontrib><creatorcontrib>Nicolson, Susan C., MD</creatorcontrib><creatorcontrib>Spray, Thomas L., MD</creatorcontrib><creatorcontrib>McDonald-McGinn, Donna, MS, CGC</creatorcontrib><creatorcontrib>Zackai, Elaine, MD</creatorcontrib><creatorcontrib>Gaynor, J. William, MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schultz, Amy H., MD, MSCE</au><au>Ittenbach, Richard F., PhD</au><au>Gerdes, Marsha, PhD</au><au>Jarvik, Gail P., MD, PhD</au><au>Wernovsky, Gil, MD</au><au>Bernbaum, Judy, MD</au><au>Solot, Cynthia, CCC, MA</au><au>Clancy, Robert R., MD</au><au>Nicolson, Susan C., MD</au><au>Spray, Thomas L., MD</au><au>McDonald-McGinn, Donna, MS, CGC</au><au>Zackai, Elaine, MD</au><au>Gaynor, J. William, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>154</volume><issue>1</issue><spage>273</spage><epage>281.e2</epage><pages>273-281.e2</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><abstract>Abstract Objectives We sought to assess the effect of congenital heart disease requiring infant surgery with cardiopulmonary bypass on neurodevelopmental outcomes and growth at 4 years of age, while matching for gestational age, socioeconomic status, maternal gestational conditions, home environment, and parental intelligence by studying multiple-gestation births. Methods We performed within-family comparison of 14 multiple-gestation births in which 1 child had congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age. Between 4 and 5 years of age, a comprehensive neurodevelopmental assessment was performed. Paired comparisons were conducted between siblings with and without heart defects using a series of nonparametric tests. Results On average, the children qualified as late preterm (mean gestational age 35.4 ± 2.6 weeks). At an average age of 4.8 ± 0.1 years, children with congenital heart disease weighed less than their siblings (median weight for age z score −0.4 vs 0.1, P = .02) and had worse performance for cognition (median full-scale IQ 99 vs 109, P = .02) and fine motor skills (median Wide Range Assessment of Visual Motor Ability, Fine Motor score 94.5 vs 107.5, P < .01). Conclusions After controlling for socioeconomic status, home environment, parental intelligence, and gestational factors by using multiple-gestation births, congenital heart disease requiring surgery with cardiopulmonary bypass at ≤6 months of age is associated with lower weight, cognitive abilities and fine motor skills at 4 years of age.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28320512</pmid><doi>10.1016/j.jtcvs.2017.02.022</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5223 |
| ispartof | The Journal of thoracic and cardiovascular surgery, 2017-07, Vol.154 (1), p.273-281.e2 |
| issn | 0022-5223 1097-685X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5481170 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | cardiac surgery Cardiopulmonary Bypass Cardiothoracic Surgery Child Development Child, Preschool complications congenital etiology Female Follow-Up Studies heart defects Heart Defects, Congenital - complications Heart Defects, Congenital - surgery Humans Infant Male Multiple Birth Offspring neurodevelopmental disorders Neurodevelopmental Disorders - etiology Time Factors triplets twins |
| title | Effect of congenital heart disease on 4-year neurodevelopment within multiple-gestation births |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T21%3A48%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20congenital%20heart%20disease%20on%204-year%20neurodevelopment%20within%20multiple-gestation%20births&rft.jtitle=The%20Journal%20of%20thoracic%20and%20cardiovascular%20surgery&rft.au=Schultz,%20Amy%20H.,%20MD,%20MSCE&rft.date=2017-07-01&rft.volume=154&rft.issue=1&rft.spage=273&rft.epage=281.e2&rft.pages=273-281.e2&rft.issn=0022-5223&rft.eissn=1097-685X&rft_id=info:doi/10.1016/j.jtcvs.2017.02.022&rft_dat=%3Cproquest_pubme%3E1879663036%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1879663036&rft_id=info:pmid/28320512&rft_els_id=S0022522317302623&rfr_iscdi=true |