A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease

Alzheimer's disease (AD), the predominant form of dementia, is highly correlated with the abnormal hyperphosphorylation and aggregation of tau. Immune responses are key drivers of AD and how they contribute to tau pathology in human disease remains largely unknown. This review summarises curren...

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Veröffentlicht in:	Experimental gerontology 2017-08, Vol.94, p.103-107
Hauptverfasser:	Barron, Matthew, Gartlon, Jane, Dawson, Lee A., Atkinson, Peter J., Pardon, Marie-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Animals Anti-Inflammatory Agents - therapeutic use Brain - drug effects Brain - metabolism Brain - pathology Brain - physiopathology Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammation - physiopathology Inflammation Mediators - metabolism Lipopolysaccharide Neuroprotective Agents - therapeutic use Phosphorylation Preclinical models Protein Aggregation, Pathological Signal Transduction Tau tau Proteins - metabolism
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