Molecular models of NS3 protease variants of the Hepatitis C virus

Hepatitis C virus (HCV) currently infects approximately three percent of the world population. In view of the lack of vaccines against HCV, there is an urgent need for an efficient treatment of the disease by an effective antiviral drug. Rational drug design has not been the primary way for discover...

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Veröffentlicht in:	BMC structural biology 2005-01, Vol.5 (1), p.1-1, Article 1
Hauptverfasser:	da Silveira, Nelson J F, Arcuri, Helen A, Bonalumi, Carlos E, de Souza, Fátima P, Mello, Isabel M V G C, Rahal, Paula, Pinho, João R R, de Azevedo, Jr, Walter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiviral Agents - pharmacology Chymotrypsin - chemistry Computational Biology - methods Crystallography, X-Ray Databases, Genetic Databases, Protein Drug Design Enzyme Inhibitors - pharmacology Genetic Variation Hepacivirus - genetics Internet Ligands Models, Molecular Molecular Sequence Data Multigene Family Peptides - chemistry Protein Conformation Protein Folding Protein Structure, Secondary Protein Structure, Tertiary RNA Helicases - genetics Serine Endopeptidases - genetics Viral Nonstructural Proteins - genetics
Online-Zugang:	Volltext
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